The role of cytokines in prostatitis

Thomas L. Jang, Anthony J Schaeffer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


There is substantiating evidence to support the role of the immune system in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Inflammation of the prostate is mediated through the cytokine-induced expression of several factors such as chemokines, inducible nitric oxide synthase, and cyclooxygenase-2. The balance between the effects of proinflammatory and anti-inflammatory cytokines determines the outcome of the inflammatory process. Several proinflammatory and anti-inflammatory cytokines have been identified in CPPS patients, their roles characterized, and their inter-relationships defined. Study of this system will provide further insights into the etiology of CP/CPPS, and lead the way for the development of novel therapeutic approaches for this morbid condition.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalWorld journal of urology
Issue number2
StatePublished - Jun 1 2003


  • Chronic pelvic pain syndrome
  • Chronic prostatitis
  • Cytokines
  • Infection
  • Inflammation

ASJC Scopus subject areas

  • Urology


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