The role of electroporation

Vladimir P. Nikolski; Igor R. Efimov

doi:10.1007/978-0-387-79403-7_18

The role of electroporation

Vladimir P. Nikolski, Igor R. Efimov

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A therapeutical application of electrical current to cardiac tissue for reviving the normal function (defibrillation, pacing) or for ablating pathological conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric field-induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some aspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro-and antiarrhythmic.

Original language	English (US)
Title of host publication	Cardiac Bioelectric Therapy
Subtitle of host publication	Mechanisms and Practical Implications
Publisher	Springer US
Pages	441-455
Number of pages	15
ISBN (Print)	9780387794020
DOIs	https://doi.org/10.1007/978-0-387-79403-7_18
State	Published - 2009

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-0-387-79403-7_18

Cite this

@inbook{eb15227a8df1477aba4723572ce5d298,

title = "The role of electroporation",

abstract = "A therapeutical application of electrical current to cardiac tissue for reviving the normal function (defibrillation, pacing) or for ablating pathological conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric field-induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some aspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro-and antiarrhythmic.",

author = "Nikolski, {Vladimir P.} and Efimov, {Igor R.}",

year = "2009",

doi = "10.1007/978-0-387-79403-7_18",

language = "English (US)",

isbn = "9780387794020",

pages = "441--455",

booktitle = "Cardiac Bioelectric Therapy",

publisher = "Springer US",

}

TY - CHAP

T1 - The role of electroporation

AU - Nikolski, Vladimir P.

AU - Efimov, Igor R.

PY - 2009

Y1 - 2009

N2 - A therapeutical application of electrical current to cardiac tissue for reviving the normal function (defibrillation, pacing) or for ablating pathological conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric field-induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some aspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro-and antiarrhythmic.

AB - A therapeutical application of electrical current to cardiac tissue for reviving the normal function (defibrillation, pacing) or for ablating pathological conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric field-induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some aspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro-and antiarrhythmic.

UR - http://www.scopus.com/inward/record.url?scp=84891436524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891436524&partnerID=8YFLogxK

U2 - 10.1007/978-0-387-79403-7_18

DO - 10.1007/978-0-387-79403-7_18

M3 - Chapter

AN - SCOPUS:84891436524

SN - 9780387794020

SP - 441

EP - 455

BT - Cardiac Bioelectric Therapy

PB - Springer US

ER -

The role of electroporation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this