The role of electroporation

Vladimir P. Nikolski; Igor R. Efimov

doi:10.1007/978-3-030-63355-4_17

The role of electroporation

Vladimir P. Nikolski^*, Igor R. Efimov

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A therapeutic application of electrical current to cardiac tissue for reviving the normal function (defibrillation, pacing) or for ablating pathological conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric-field-induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some aspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro- and antiarrhythmic.

Original language	English (US)
Title of host publication	Cardiac Bioelectric Therapy
Subtitle of host publication	Mechanisms and Practical Implications
Publisher	Springer International Publishing
Pages	233-241
Number of pages	9
ISBN (Electronic)	9783030633554
ISBN (Print)	9783030633547
DOIs	https://doi.org/10.1007/978-3-030-63355-4_17
State	Published - Jan 28 2021

Keywords

Ablation
Defibrillation
Electroporation
Optical mapping
Pacing
Propidium iodide

ASJC Scopus subject areas

General Medicine
General Health Professions

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10.1007/978-3-030-63355-4_17

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abstract = "A therapeutic application of electrical current to cardiac tissue for reviving the normal function (defibrillation, pacing) or for ablating pathological conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric-field-induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some aspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro- and antiarrhythmic.",

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AU - Efimov, Igor R.

PY - 2021/1/28

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N2 - A therapeutic application of electrical current to cardiac tissue for reviving the normal function (defibrillation, pacing) or for ablating pathological conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric-field-induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some aspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro- and antiarrhythmic.

AB - A therapeutic application of electrical current to cardiac tissue for reviving the normal function (defibrillation, pacing) or for ablating pathological conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric-field-induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some aspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro- and antiarrhythmic.

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KW - Defibrillation

KW - Electroporation

KW - Optical mapping

KW - Pacing

KW - Propidium iodide

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The role of electroporation

Abstract

Keywords

ASJC Scopus subject areas

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