The role of electroporation

Vladimir P. Nikolski*, Igor R. Efimov

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


A therapeutic application of electrical current to cardiac tissue for reviving the normal function (defibrillation, pacing) or for ablating pathological conduction pathways inevitably has to take into account the phenomenon of electroporation, the electric-field-induced rupture of sarcolemma that is usually evidenced by a drastic unselective increase in cell membrane permeability to small ions and large molecules. This chapter describes some aspects of this phenomenon in relation to cardiac therapy and research. Particularly, it provides evidences that (1) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field and (2) electroporation can affect the outcome of defibrillation therapy, being both pro- and antiarrhythmic.

Original languageEnglish (US)
Title of host publicationCardiac Bioelectric Therapy
Subtitle of host publicationMechanisms and Practical Implications
PublisherSpringer International Publishing
Number of pages9
ISBN (Electronic)9783030633554
ISBN (Print)9783030633547
StatePublished - Jan 28 2021


  • Ablation
  • Defibrillation
  • Electroporation
  • Optical mapping
  • Pacing
  • Propidium iodide

ASJC Scopus subject areas

  • Medicine(all)
  • Health Professions(all)


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