The role of enhancer RNAs in epigenetic regulation of gene expression

Homa Rahnamoun; Paola Orozco; Shannon M. Lauberth

doi:10.1080/21541264.2019.1698934

The role of enhancer RNAs in epigenetic regulation of gene expression

Homa Rahnamoun, Paola Orozco, Shannon M. Lauberth^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

Original language	English (US)
Pages (from-to)	19-25
Number of pages	7
Journal	Transcription
Volume	11
Issue number	1
DOIs	https://doi.org/10.1080/21541264.2019.1698934
State	Published - Jan 1 2020

Funding

S.M.L is supported by NIH grant R35 GM128900-01. H.R. is supported by National Science Foundation Graduate Research Fellowship (NSF-GRFP) and the NIH T32 GM007240).

Keywords

BRD4
Enhancer
bromodomain
chromatin
eRNA
gene regulation
histone modification
transcription

ASJC Scopus subject areas

Genetics
Biochemistry
Biotechnology

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10.1080/21541264.2019.1698934

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AB - Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

KW - BRD4

KW - Enhancer

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KW - eRNA

KW - gene regulation

KW - histone modification

KW - transcription

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The role of enhancer RNAs in epigenetic regulation of gene expression

Abstract

Funding

Keywords

ASJC Scopus subject areas

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