The role of enhancer RNAs in epigenetic regulation of gene expression

Homa Rahnamoun, Paola Orozco, Shannon M. Lauberth*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalTranscription
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • BRD4
  • Enhancer
  • bromodomain
  • chromatin
  • eRNA
  • gene regulation
  • histone modification
  • transcription

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics

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