The role of enhancer RNAs in epigenetic regulation of gene expression

Homa Rahnamoun; Paola Orozco; Shannon M. Lauberth

doi:10.1080/21541264.2019.1698934

The role of enhancer RNAs in epigenetic regulation of gene expression

Homa Rahnamoun, Paola Orozco, Shannon M. Lauberth^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

Original language	English (US)
Pages (from-to)	19-25
Number of pages	7
Journal	Transcription
Volume	11
Issue number	1
DOIs	https://doi.org/10.1080/21541264.2019.1698934
State	Published - Jan 1 2020
Externally published	Yes

Keywords

BRD4
Enhancer
bromodomain
chromatin
eRNA
gene regulation
histone modification
transcription

ASJC Scopus subject areas

Genetics
Biochemistry
Biotechnology

Access to Document

10.1080/21541264.2019.1698934

Cite this

@article{bc414fd5656c4911b95d10572a0701d3,

title = "The role of enhancer RNAs in epigenetic regulation of gene expression",

abstract = "Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.",

keywords = "BRD4, Enhancer, bromodomain, chromatin, eRNA, gene regulation, histone modification, transcription",

author = "Homa Rahnamoun and Paola Orozco and Lauberth, {Shannon M.}",

note = "Funding Information: S.M.L is supported by NIH grant R35 GM128900-01. H.R. is supported by National Science Foundation Graduate Research Fellowship (NSF-GRFP) and the NIH T32 GM007240). Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2020",

month = jan,

day = "1",

doi = "10.1080/21541264.2019.1698934",

language = "English (US)",

volume = "11",

pages = "19--25",

journal = "Transcription",

issn = "2154-1264",

publisher = "Friedrich-Berlin-Verlag",

number = "1",

}

TY - JOUR

T1 - The role of enhancer RNAs in epigenetic regulation of gene expression

AU - Rahnamoun, Homa

AU - Orozco, Paola

AU - Lauberth, Shannon M.

N1 - Funding Information: S.M.L is supported by NIH grant R35 GM128900-01. H.R. is supported by National Science Foundation Graduate Research Fellowship (NSF-GRFP) and the NIH T32 GM007240). Publisher Copyright: © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

AB - Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

KW - BRD4

KW - Enhancer

KW - bromodomain

KW - chromatin

KW - eRNA

KW - gene regulation

KW - histone modification

KW - transcription

UR - http://www.scopus.com/inward/record.url?scp=85076825823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076825823&partnerID=8YFLogxK

U2 - 10.1080/21541264.2019.1698934

DO - 10.1080/21541264.2019.1698934

M3 - Article

C2 - 31823686

AN - SCOPUS:85076825823

SN - 2154-1264

VL - 11

SP - 19

EP - 25

JO - Transcription

JF - Transcription

IS - 1

ER -

The role of enhancer RNAs in epigenetic regulation of gene expression

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this