The role of extracellular matrix proteins in neural stem cell migration and traumatic brain injury: A basis for novel tissue engineering strategies

Matthew C. Tate; Clara L. Caltagirone; David R. Archer; Andrés J. García; Michelle C. LaPlaca

The role of extracellular matrix proteins in neural stem cell migration and traumatic brain injury: A basis for novel tissue engineering strategies

Matthew C. Tate^*, Clara L. Caltagirone, David R. Archer, Andrés J. García, Michelle C. LaPlaca

^*Corresponding author for this work

Neurological Surgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The ability of donor cells to adhere and migrate ECM proteins as a primary component for tissue-engineered constructs in the injured brain was investigated. Primary FGF2-responsive neural stem cells adhered and migrated on FN and LN under serum-free conditions with respect to collagens, chondroitin sulfate proteoglycan, poly-L-lysine, and uncoated tissue culture polystyrene. FN and LN immunoreactivity was increased in injured brains, adjacent to the brain cavity on day 1 after injury. The results showed significant increases in survival and migration distance in the transplant. It was suggested that tissue engineering utilizing neural stem cells cultured on an ECM-based scaffold can provide a novel strategy for influencing transplants.

Original language	English (US)
Title of host publication	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Number of pages	1
State	Published - Dec 1 2002
Event	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States Duration: Oct 13 2002 → Oct 16 2002

Other

Other	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Country/Territory	United States
City	Atlanta, GA
Period	10/13/02 → 10/16/02

ASJC Scopus subject areas

Engineering(all)

Cite this

@inproceedings{c76500f740f14290aa6817751e9886f0,

title = "The role of extracellular matrix proteins in neural stem cell migration and traumatic brain injury: A basis for novel tissue engineering strategies",

abstract = "The ability of donor cells to adhere and migrate ECM proteins as a primary component for tissue-engineered constructs in the injured brain was investigated. Primary FGF2-responsive neural stem cells adhered and migrated on FN and LN under serum-free conditions with respect to collagens, chondroitin sulfate proteoglycan, poly-L-lysine, and uncoated tissue culture polystyrene. FN and LN immunoreactivity was increased in injured brains, adjacent to the brain cavity on day 1 after injury. The results showed significant increases in survival and migration distance in the transplant. It was suggested that tissue engineering utilizing neural stem cells cultured on an ECM-based scaffold can provide a novel strategy for influencing transplants.",

author = "Tate, {Matthew C.} and Caltagirone, {Clara L.} and Archer, {David R.} and Garc{\'i}a, {Andr{\'e}s J.} and LaPlaca, {Michelle C.}",

year = "2002",

month = dec,

day = "1",

language = "English (US)",

booktitle = "Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products",

note = "Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products ; Conference date: 13-10-2002 Through 16-10-2002",

}

Tate, MC, Caltagirone, CL, Archer, DR, García, AJ & LaPlaca, MC 2002, The role of extracellular matrix proteins in neural stem cell migration and traumatic brain injury: A basis for novel tissue engineering strategies. in Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products., CT-3, Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products, Atlanta, GA, United States, 10/13/02.

The role of extracellular matrix proteins in neural stem cell migration and traumatic brain injury : A basis for novel tissue engineering strategies. / Tate, Matthew C.; Caltagirone, Clara L.; Archer, David R. et al.

Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. 2002. CT-3.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - The role of extracellular matrix proteins in neural stem cell migration and traumatic brain injury

T2 - Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

AU - Tate, Matthew C.

AU - Caltagirone, Clara L.

AU - Archer, David R.

AU - García, Andrés J.

AU - LaPlaca, Michelle C.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - The ability of donor cells to adhere and migrate ECM proteins as a primary component for tissue-engineered constructs in the injured brain was investigated. Primary FGF2-responsive neural stem cells adhered and migrated on FN and LN under serum-free conditions with respect to collagens, chondroitin sulfate proteoglycan, poly-L-lysine, and uncoated tissue culture polystyrene. FN and LN immunoreactivity was increased in injured brains, adjacent to the brain cavity on day 1 after injury. The results showed significant increases in survival and migration distance in the transplant. It was suggested that tissue engineering utilizing neural stem cells cultured on an ECM-based scaffold can provide a novel strategy for influencing transplants.

AB - The ability of donor cells to adhere and migrate ECM proteins as a primary component for tissue-engineered constructs in the injured brain was investigated. Primary FGF2-responsive neural stem cells adhered and migrated on FN and LN under serum-free conditions with respect to collagens, chondroitin sulfate proteoglycan, poly-L-lysine, and uncoated tissue culture polystyrene. FN and LN immunoreactivity was increased in injured brains, adjacent to the brain cavity on day 1 after injury. The results showed significant increases in survival and migration distance in the transplant. It was suggested that tissue engineering utilizing neural stem cells cultured on an ECM-based scaffold can provide a novel strategy for influencing transplants.

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M3 - Conference contribution

AN - SCOPUS:18644374738

BT - Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products

Y2 - 13 October 2002 through 16 October 2002

ER -

The role of extracellular matrix proteins in neural stem cell migration and traumatic brain injury: A basis for novel tissue engineering strategies

Abstract

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ASJC Scopus subject areas

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