The Role of Global and Local Ancestry on Clopidogrel Response in African Americans

Guang Yang, Cristina Alarcon, Paula Friedman, Li Gong, Teri Klein, Travis Obrien, Edith A. Nutescu, Matthew Tuck, David Meltzer, Minoli A. Perera

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations

Abstract

Pharmacogenomics has long lacked dedicated studies in African Americans, resulting in a lack of indepth data in this populations. The ACCOuNT consortium has collected a cohort of 167 African American patients on steady state clopidogrel with the goal of discovering population specific variation that may contribute to the response of this anti-platelet agent. Here we analyze the role of both global and local ancestry on the clinical phenotypes of P2Y12 reaction units (PRU) and high on-treatment platelet reactivity (HTPR) in this cohort. We found that local ancestry at the TSS of three genes, IRS-1, ABCB1 and KDR were nominally associated with PRU, and local ancestry-adjusted SNP association identified variants in ITGA2 associated to increased PRU. These finding help to explain the variability in drug response seen in African Americans, especially as few studies on genes outside of CYP2C19 has been conducted in this population.

Original languageEnglish (US)
Pages (from-to)221-232
Number of pages12
JournalPacific Symposium on Biocomputing
Issue number2023
DOIs
StatePublished - 2023
Event28th Pacific Symposium on Biocomputing, PSB 2023 - Kohala Coast, United States
Duration: Jan 3 2023Jan 7 2023

Funding

Acknowledgments This work was supported by 1U54MD010723 and the participants in ACCOuNT studies along with the physicians, nurses and clinical recruiters that enabled the gathering of this data.

Keywords

  • African American
  • Ancestry
  • Clopidogrel
  • Pharmacogenomics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Computational Theory and Mathematics

Fingerprint

Dive into the research topics of 'The Role of Global and Local Ancestry on Clopidogrel Response in African Americans'. Together they form a unique fingerprint.

Cite this