The role of inflammation in Leukaemia

Janusz Krawczyk, Michael O'Dwyer, Ronan Swords, Ciara Freeman, Francis J. Giles*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Acute leukaemias are a group of malignancies characterised by the invasion of the bone marrow by immature haematopoietic precursors and differentiation arrest at various maturation steps. Multiplicity of intrinsic and extrinsic factors influences the transformation and progression of leukaemia. The intrinsic factors encompass genetic alterations of cellular pathways leading to the activation of, among others, inflammatory pathways (such as nuclear factor kappa B). The extrinsic components include, among others, the inflammatory pathways activated by the bone marrow microenvironment and include chemokines, cytokines and adhesion molecules. In this chapter, we review the role of inflammatory processes in the transformation, survival and proliferation of leukaemias, particularly the role of nuclear factor kappa B and its downstream signalling in leukaemias and the novel therapeutic strategies that exploit potentially unique properties of inflammatory signalling that offer interesting options for future therapeutic interventions.

Original languageEnglish (US)
Title of host publicationInflammation and Cancer
PublisherSpringer New York LLC
Pages335-360
Number of pages26
ISBN (Print)9783034808361
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume816
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Krawczyk, J., O'Dwyer, M., Swords, R., Freeman, C., & Giles, F. J. (2014). The role of inflammation in Leukaemia. In Inflammation and Cancer (pp. 335-360). (Advances in Experimental Medicine and Biology; Vol. 816). Springer New York LLC. https://doi.org/10.1007/978-3-348-837-8_13