The role of iron as a mediator of oxidative stress in Alzheimer disease

Rudy J. Castellani*, Paula I. Moreira, George Perry, Xiongwei Zhu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations

Abstract

Iron is both essential for maintaining a spectrum of metabolic processes in the central nervous system and elsewhere, and potent source of reactive oxygen species. Redox balance with respect to iron, therefore, may be critical to human neurodegenerative disease but is also in need of better understanding. Alzheimer disease (AD) in particular is associated with accumulation of numerous markers of oxidative stress; moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress. In this review, we discuss the role of iron in the progression of AD.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalBioFactors
Volume38
Issue number2
DOIs
StatePublished - Mar 2012

Keywords

  • Alzheimer disease
  • Chelation
  • Neurodegeneration
  • Oxidative stress
  • Redox active iron

ASJC Scopus subject areas

  • Molecular Medicine
  • Biochemistry
  • Clinical Biochemistry

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