The role of left inferior fronto-occipital fascicle in verbal perseveration: A brain electrostimulation mapping study

Osaama H. Khan, Guillaume Herbet, Sylvie Moritz-Gasser, Hugues Duffau*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The subcortical connectivity underlying verbal perseveration (VP) remains poorly understood. We have previously reported that intraoperative electrical stimulation of the caudate nucleus during awake surgery resulted in VP. Here, our purpose is to study the white matter pathway underlying VP using subcortical stimulation mapping in a series of patients who underwent glioma resection. Eleven patients with a left hemispheric low grade glioma were operated on while awake. Intraoperative direct electrical stimulation was used both at cortical and subcortical levels while the patients carried out motor and naming tasks during the resection. All patients experienced VP during electrical stimulation performed at the level of different subcortical locations, which corresponded in the 11 cases to different parts of the left inferior frontooccipital fascicle. Perseveration persisted into the postoperative days, but resolved completely by three months.Our original findings provide further insight into the neuroanatomical basis of VP, by supporting the role of left inferior fronto-occipital fascicle. Such data may have both fundamental and clinical implications.

Original languageEnglish (US)
Pages (from-to)403-411
Number of pages9
JournalBrain Topography
Volume27
Issue number3
DOIs
StatePublished - May 2014

Keywords

  • Awake surgery
  • Brain connectivity
  • Inferior frontooccipital fascicle
  • Subcortical electrostimulation mapping
  • Verbal perseveration

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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