The role of loperamide in gastrointestinal disorders

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


Loperamide is an effective therapy for a variety of diarrheal syndromes, including acute, nonspecific (infectious) diarrhea; traveler's diarrhea; and chemotherapy-related and protease inhibitor-associated diarrhea. Loperamide is effective for the "gut-directed" symptom of diarrhea in patients with painless diarrhea or diarrhea-predominant irritable bowel syndrome. Loperamide and diphenoxylate are commonly used to treat diarrhea in numerous settings of inflammatory bowel disease. Loperamide has also been observed to increase anal sphincter tone, which may lead to improvement of fecal continence in patients with and without diarrhea. Loperamide is generally well tolerated at recommended nonprescription doses, with the most common side effects related to the impact on bowel motility (abdominal pain, distention, bloating, nausea, vomiting, and constipation).

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalReviews in gastroenterological disorders
Issue number1
StatePublished - Dec 2008


  • Chemotherapy
  • Diarrhea
  • Incontinence, fecal
  • Inflammatory bowel disease
  • Irritable bowel syndrome
  • Loperamide
  • Microscopic colitis
  • Traveler's diarrhea

ASJC Scopus subject areas

  • Gastroenterology


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