The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos

M. Via*, A. De Giacomo, H. Corvol, C. Eng, M. A. Seibold, C. Gillett, J. Galanter, S. Sen, H. Tcheurekdjian, R. Chapela, J. R. Rodríguez-Santana, W. Rodríguez-Cintrón, S. Thyne, P. C. Avila, S. Choudhry, E. González Burchard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background: Leukotrienes play an important role in allergic and inflammatory diseases, but reports on the involvement of arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and leukotriene A4 hydrolase (LTA4H) in asthma have been inconclusive. Objective: To determine whether polymorphisms in ALOX5AP and LTA4H genes are risk factors for asthma in two different Latino groups: Mexicans and Puerto Ricans. Methods: The LTA4H gene was sequenced in individuals from both groups to identify novel polymorphisms. Single-nucleotide polymorphisms (SNPs) in the ALOX5AP and LTA4H genes were analysed for associations with asthma and asthma-related phenotypes in 687 parent-child trios of Mexican and Puerto Rican origin. Results: In LTA4H, five previously unknown polymorphisms were identified. Two SNPs within LTA4H (rs17525488 and rs2540493) were protective for asthma in Latinos (P=0.007 and 0.05, respectively). Among the Mexican patients, LTA4H polymorphisms were associated with baseline lung function and IgE levels. For ALOX5AP, the minor allele at SNP rs10507391 was associated with protection from asthma (odds ratio=0.78, P=0.02) and baseline lung function (P=0.018) in Puerto Ricans. A gene-gene interaction was identified between LTA4H (rs17525488) and ALOX5AP (rs10507391), (P=0.003, in the combined sample). Conclusion: Our results support the role of LTA4H and ALOX5AP variants as risk factors for asthma in Latino populations.

Original languageEnglish (US)
Pages (from-to)582-589
Number of pages8
JournalClinical and Experimental Allergy
Volume40
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • Association study
  • Asthma
  • Latino populations
  • Leukotriene

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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