The role of macrophages in the resolution of inflammation

Satoshi Watanabe, Michael Alexander, Alexander V. Misharin, G. R.Scott Budinger*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations

Abstract

Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis.

Original languageEnglish (US)
Pages (from-to)2619-2628
Number of pages10
JournalJournal of Clinical Investigation
Volume129
Issue number7
DOIs
StatePublished - 2019

ASJC Scopus subject areas

  • Medicine(all)

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