The role of macrophages in the resolution of inflammation

Satoshi Watanabe; Michael Alexander; Alexander V. Misharin; G. R.Scott Budinger

doi:10.1172/JCI124615

The role of macrophages in the resolution of inflammation

Satoshi Watanabe, Michael Alexander, Alexander V. Misharin, G. R.Scott Budinger^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

617 Scopus citations

Abstract

Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis.

Original language	English (US)
Pages (from-to)	2619-2628
Number of pages	10
Journal	Journal of Clinical Investigation
Volume	129
Issue number	7
DOIs	https://doi.org/10.1172/JCI124615
State	Published - 2019

Funding

SW is supported by MSD Life Science Foundation, Public Interest Incorporated Foundation; and a David W. Cugell and Christina Enroth-Cugell Fellowship. AVM is supported by NIH grants HL135124 and AI135964, Department of Defense grant PR141319, and NIH/ National Institute of Allergy and Infectious Diseases (NIAID) grant AI135964. GRSB is supported by NIH grants ES013995, HL071643, and AG049665, Veterans Administration grant BX000201, Department of Defense grant PR141319, and NIH/NIAID grant AI135964.

ASJC Scopus subject areas

General Medicine

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10.1172/JCI124615

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title = "The role of macrophages in the resolution of inflammation",

abstract = "Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis.",

author = "Satoshi Watanabe and Michael Alexander and Misharin, {Alexander V.} and Budinger, {G. R.Scott}",

note = "Funding Information: SW is supported by MSD Life Science Foundation, Public Interest Incorporated Foundation; and a David W. Cugell and Christina Enroth-Cugell Fellowship. AVM is supported by NIH grants HL135124 and AI135964, Department of Defense grant PR141319, and NIH/ National Institute of Allergy and Infectious Diseases (NIAID) grant AI135964. GRSB is supported by NIH grants ES013995, HL071643, and AG049665, Veterans Administration grant BX000201, Department of Defense grant PR141319, and NIH/NIAID grant AI135964. Publisher Copyright: {\textcopyright} 2019 American Society for Clinical Investigation.",

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AB - Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis.

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The role of macrophages in the resolution of inflammation

Abstract

Funding

ASJC Scopus subject areas

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