The role of metabolic syndrome in heart failure

Pasquale Perrone-Filardi*, Stefania Paolillo, Pierluigi Costanzo, Gianluigi Savarese, Bruno Trimarco, Robert O. Bonow

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


Metabolic syndrome (MS) is a highly prevalent condition in patients affected by heart failure (HF); however, it is still unclear whether, in the setting of cardiac dysfunction, it represents an adverse risk factor for the occurrence of cardiac events. The epidemiologic implications of MS in HF have been studied intensely, as many of its components contribute to the incidence and severity of HF. In particular, insulin resistance, diabetes mellitus, and lipid abnormalities represent the main components that negatively influence disease progression and evolution. Yet, other components of the MS, i.e. overweight/obesity and high blood pressure, are favourably associated with outcome in HF patients. The aim of this review was to report epidemiology and prognostic role of MS in HF and to investigate current clinical implications and future research needs.

Original languageEnglish (US)
Pages (from-to)2630-2634
Number of pages5
JournalEuropean heart journal
Issue number39
StatePublished - Oct 14 2015


  • Heart failure
  • Insulin resistance
  • Metabolic syndrome
  • Obesity paradox

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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