The role of microRNAs in Epstein-Barr virus latency and lytic reactivation

Eleonora Forte, Micah A. Luftig*

*Corresponding author for this work

Research output: Contribution to journalShort survey

42 Scopus citations

Abstract

Oncogenic viruses reprogram host gene expression driving proliferation, ensuring survival, and evading the immune response. The recent appreciation of microRNAs (miRNAs) as small non-coding RNAs that broadly regulate gene expression has provided new insight into this complex scheme of host control. This review highlights the role of viral and cellular miRNAs during the latent and lytic phases of the EBV life cycle.

Original languageEnglish (US)
Pages (from-to)1156-1167
Number of pages12
JournalMicrobes and Infection
Volume13
Issue number14-15
DOIs
StatePublished - Dec 1 2011

Keywords

  • B-cell lymphoma
  • Epstein-Barr virus, EBV
  • LMP1
  • Lytic reactivation
  • MicroRNA, miRNA
  • MiR-146
  • MiR-155
  • MiR-200
  • MiR-34
  • ZEB

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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