The role of mitochondrial fusion and fission in the process of cardiac oxidative stress

Fei Yu, Eltyeb Abdelwahid, Tao Xu, Longgang Hu, Man Wang, Yuzhen Li, Bassam Felipe Mogharbel, Katherine Athayde Teixeira de Carvalho, Luiz Cesar Guarita-Souza, Yi An, Peifng Li

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Mitochondria are the energy suppliers in the cell and undergo constant fusion and fission to meet metabolic demand during the cell life cycle. Well-balanced mitochondrial dynamics are extremely important and necessary for cell survival as well as for tissue homeostasis. Cardiomyocytes contain large numbers of mitochondria to satisfy the high energy demand. It has been established that deregulated processes of mitochondrial dynamics play a major role in myocardial cell death. Currently, cardiac mitochondrial cell death pathways attract great attention in the cell biology and regenerative medicine fields. Importantly, mitochondrial dynamics are tightly linked to oxidative stress-induced cardiac damage. This review summarizes molecular mechanisms of mitochondrial fusion and fission processes and their potential roles in myocardial cell death triggered by oxidative stress. Advances in understanding the effect of both normal and abnormal mitochondrial dynamics on heart protection will lead to significant improvement of therapeutic discoveries.

Original languageEnglish (US)
Pages (from-to)541-552
Number of pages12
JournalHistology and histopathology
Volume35
Issue number6
DOIs
StatePublished - 2020

Keywords

  • Cardiac system
  • Cell death
  • Mitochondrial dynamic
  • Oxidative stress

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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