The role of n-3 PUFAs in preventing the arrhythmic risk in patients with idiopathic dilated cardiomyopathy

Savina Nodari, Marco Metra*, Giuseppe Milesi, Alessandra Manerba, Bruno Mario Cesana, Mihai Gheorghiade, Livio Dei Cas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Background: N-3 polyunsaturated fatty acids (n-3 PUFAs) intake is associated with a reduction in sudden cardiac death in patients with ischemic heart disease. Their effects in ptients with heart failure caused by idiopathic dilated cardiomyopathy (IDC) are unknown. Methods: We compared with placebo the effects of n-3 PUFAs administration in 44 patients with IDC and with frequent or repetitive ventricular arrhythmias at Holter monitoring using a randomized, double-blind design. Arrhythmic risk was assessed by microvolt T-wave analysis (MTWA), signal averaged ECG (SAECG), Holter monitoring, power spectral analysis of heart rate (HR) variability, catecholamine and cytokine plasma levels, at baseline and after 6 months. Results: At MTWA, 7/12 patients (58%) initially positive became negative after n-3 PUFAs while one patient became positive after placebo (p∈=∈0.019). N-3 PUFAs administration was also associated to normalization of SAECG (11/15 patients, p∈<∈0.0015), decrease in non-sustained ventricular tachycardia (NSVT) episodes (p∈=∈0.0002) and NSVT HR (p∈=∈0.0003), improvement in HR variability and decrease in catecholamine and cytokine plasma levels. The ratio of plasma n-6 PUFAs to n-3 PUFAs decreased from 12.01 to 3.48 after n-3 PUFAs. Conclustions: N-3 PUFAs administration is associated with favorable effects on parameters related to arrhythmic risk in patients with idiopathic dilated cardiomyopathy. These results are consistent with antiarrhythmic activity independent from their antiischemic effects.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalCardiovascular Drugs and Therapy
Volume23
Issue number1
DOIs
StatePublished - Feb 1 2009

Keywords

  • Heart failure
  • N-3 PUFAs
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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