TY - JOUR
T1 - The role of n-3 PUFAs in preventing the arrhythmic risk in patients with idiopathic dilated cardiomyopathy
AU - Nodari, Savina
AU - Metra, Marco
AU - Milesi, Giuseppe
AU - Manerba, Alessandra
AU - Cesana, Bruno Mario
AU - Gheorghiade, Mihai
AU - Dei Cas, Livio
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Background: N-3 polyunsaturated fatty acids (n-3 PUFAs) intake is associated with a reduction in sudden cardiac death in patients with ischemic heart disease. Their effects in ptients with heart failure caused by idiopathic dilated cardiomyopathy (IDC) are unknown. Methods: We compared with placebo the effects of n-3 PUFAs administration in 44 patients with IDC and with frequent or repetitive ventricular arrhythmias at Holter monitoring using a randomized, double-blind design. Arrhythmic risk was assessed by microvolt T-wave analysis (MTWA), signal averaged ECG (SAECG), Holter monitoring, power spectral analysis of heart rate (HR) variability, catecholamine and cytokine plasma levels, at baseline and after 6 months. Results: At MTWA, 7/12 patients (58%) initially positive became negative after n-3 PUFAs while one patient became positive after placebo (p∈=∈0.019). N-3 PUFAs administration was also associated to normalization of SAECG (11/15 patients, p∈<∈0.0015), decrease in non-sustained ventricular tachycardia (NSVT) episodes (p∈=∈0.0002) and NSVT HR (p∈=∈0.0003), improvement in HR variability and decrease in catecholamine and cytokine plasma levels. The ratio of plasma n-6 PUFAs to n-3 PUFAs decreased from 12.01 to 3.48 after n-3 PUFAs. Conclustions: N-3 PUFAs administration is associated with favorable effects on parameters related to arrhythmic risk in patients with idiopathic dilated cardiomyopathy. These results are consistent with antiarrhythmic activity independent from their antiischemic effects.
AB - Background: N-3 polyunsaturated fatty acids (n-3 PUFAs) intake is associated with a reduction in sudden cardiac death in patients with ischemic heart disease. Their effects in ptients with heart failure caused by idiopathic dilated cardiomyopathy (IDC) are unknown. Methods: We compared with placebo the effects of n-3 PUFAs administration in 44 patients with IDC and with frequent or repetitive ventricular arrhythmias at Holter monitoring using a randomized, double-blind design. Arrhythmic risk was assessed by microvolt T-wave analysis (MTWA), signal averaged ECG (SAECG), Holter monitoring, power spectral analysis of heart rate (HR) variability, catecholamine and cytokine plasma levels, at baseline and after 6 months. Results: At MTWA, 7/12 patients (58%) initially positive became negative after n-3 PUFAs while one patient became positive after placebo (p∈=∈0.019). N-3 PUFAs administration was also associated to normalization of SAECG (11/15 patients, p∈<∈0.0015), decrease in non-sustained ventricular tachycardia (NSVT) episodes (p∈=∈0.0002) and NSVT HR (p∈=∈0.0003), improvement in HR variability and decrease in catecholamine and cytokine plasma levels. The ratio of plasma n-6 PUFAs to n-3 PUFAs decreased from 12.01 to 3.48 after n-3 PUFAs. Conclustions: N-3 PUFAs administration is associated with favorable effects on parameters related to arrhythmic risk in patients with idiopathic dilated cardiomyopathy. These results are consistent with antiarrhythmic activity independent from their antiischemic effects.
KW - Heart failure
KW - N-3 PUFAs
KW - Ventricular arrhythmias
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U2 - 10.1007/s10557-008-6142-7
DO - 10.1007/s10557-008-6142-7
M3 - Article
C2 - 18982439
AN - SCOPUS:58549111004
SN - 0920-3206
VL - 23
SP - 5
EP - 15
JO - Cardiovascular Drugs and Therapy
JF - Cardiovascular Drugs and Therapy
IS - 1
ER -