The role of natural killer cells in the pathogenesis of Epstein-Barr virus-associated Burkitt lymphoma in a SCID mouse model

B. Z. Katz*, B. Salimi, U. Saini, J. G. McNamara, R. N. Eisen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Epstein-Barr virus (EBV) is associated with both benign and malignant lymphoproliferative processes. Recently, mice with severe combined immunodeficiency (SCID) have been described that develop EBV-induced lymphomas when inoculated with peripheral blood lymphocytes from EBV-seropositive individuals. To investigate the pathogenesis of EBV-associated Burkitt lymphomas, we intraperitoneally inoculated SCID mice with cells from EBV-infected Burkitt lymphoma (BL) cell lines. In general, cells from BL lines developed into BL-like tumors. Certain BL cell lines, however, were not particularly tumorigenic in these animals. Antibody capable of depleting mice of natural killer cells (anti-asialo GM1) favored the development of these Burkitt lymphomas. The pathogenetic implications of this animal model for human disease is discussed.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalInternational journal of oncology
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1994

Keywords

  • Burkitt lymphoma
  • Epstein-Barr virus
  • SCID mouse
  • natural killer cells

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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