The role of nitric oxide in mediating tumour blood flow

George Van Buren, E. Ramsay Camp, Anthony D. Yang, Michael J. Gray, Fan Fan, Ray Somcio, Lee M. Ellis*

*Corresponding author for this work

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Nitric oxide (NO) is a ubiquitous molecule with a myriad of physiological and pathophysiological roles. It has numerous direct and indirect effects on tumour vasculature as both a regulatory and effector molecule. NO affects tumour blood flow through its effects on tumour angiogenesis, vascular tone and vascular permeability, partly via its interaction with vascular endothelial growth factor. In this review, the authors examine the basic tenants of NO biology, the association of NO with tumour progression, and the role NO plays in mediating alterations in vascular functions in tumours.

Original languageEnglish (US)
Pages (from-to)689-701
Number of pages13
JournalExpert Opinion on Therapeutic Targets
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2006

Keywords

  • Angiogenesis
  • Blood flow
  • Nitric oxide
  • Pericyte

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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  • Cite this

    Van Buren, G., Camp, E. R., Yang, A. D., Gray, M. J., Fan, F., Somcio, R., & Ellis, L. M. (2006). The role of nitric oxide in mediating tumour blood flow. Expert Opinion on Therapeutic Targets, 10(5), 689-701. https://doi.org/10.1517/14728222.10.5.689