The role of nucleotide-binding oligomerization domain-like receptors in pulmonary infection

Kristin M. Wiese*, Bria M. Coates, Karen M. Ridge

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Pneumonia is caused by both viral and bacterial pathogens and is responsible for a significant health burden in the Unites States. The innate immune system is the human body's first line of defense against these pathogens. The recognition of invading pathogens via pattern recognition receptors leads to proinflammatory cytokine and chemokine production, followed by recruitment and activation of effector immune cells. The nonspecific inflammatory nature of the innate immune response can result in immunopathology that is detrimental to the host. In this review, we focus on one class of pattern recognition receptors, the nucleotide-binding oligomerization domain (NOD)-like receptors, specifically NOD1 and NOD2, and their role in host defense against viral and bacterial pathogens of the lung, including influenza, respiratory syncytial virus, Streptococcus pneumoniae, Chlamydophila pneumoniae, and Staphylococcus aureus. It is hoped that improved understanding of NOD1 and NOD2 activity in pneumonia will facilitate the development of novel therapies and promote improved patient outcomes.

Original languageEnglish (US)
Pages (from-to)151-161
Number of pages11
JournalAmerican journal of respiratory cell and molecular biology
Issue number2
StatePublished - Aug 2017


  • Influenza
  • Innate immunity
  • NOD like receptors
  • Pulmonary infections
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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