The role of oxazolidinones in L-proline-assisted aldol-type reactions

Ivan A. Konstantinov, Linda J Broadbelt

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In this study, the formation of oxazolidinone intermediates along the reaction coordinates of two L-proline-catalyzed reactions was investigated using high-level quantum mechanical calculations. Our results suggest that the final product is produced via routes other than the currently-adopted catalytic cycle for L-proline, including routes where oxazolidinones are directly involved.

Original languageEnglish (US)
Pages (from-to)1031-1038
Number of pages8
JournalTopics in Catalysis
Volume53
Issue number15-18
DOIs
StatePublished - Sep 1 2010

Keywords

  • Aldol reactions
  • DFT
  • L-proline
  • Oxazolidinones

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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