The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain

Rachel E. Miller; Phuong B. Tran; Alia M. Obeidat; Padmanabhan Raghu; Shingo Ishihara; Richard J. Miller; Anne Marie Malfait

doi:10.1007/s11914-015-0280-1

The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain

Rachel E. Miller, Phuong B. Tran, Alia M. Obeidat, Padmanabhan Raghu, Shingo Ishihara, Richard J. Miller, Anne Marie Malfait^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous systems that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.

Original language	English (US)
Pages (from-to)	318-326
Number of pages	9
Journal	Current Osteoporosis Reports
Volume	13
Issue number	5
DOIs	https://doi.org/10.1007/s11914-015-0280-1
State	Published - Oct 7 2015

Funding

Rachel Miller was supported by the US National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (F32AR062927).

Keywords

Animal models
Nerve growth factor
Osteoarthritis
Pain
Sensitization
Sodium channels

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11914-015-0280-1

Cite this

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title = "The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain",

abstract = "Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous systems that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.",

keywords = "Animal models, Nerve growth factor, Osteoarthritis, Pain, Sensitization, Sodium channels",

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AU - Raghu, Padmanabhan

AU - Ishihara, Shingo

AU - Miller, Richard J.

AU - Malfait, Anne Marie

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N2 - Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous systems that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.

AB - Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous systems that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.

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KW - Sensitization

KW - Sodium channels

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The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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