The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain

Rachel E. Miller, Phuong B. Tran, Alia M. Obeidat, Padmanabhan Raghu, Shingo Ishihara, Richard J. Miller, Anne Marie Malfait*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Knee osteoarthritis is characterized by progressive damage and remodeling of all tissues in the knee joint. Pain is the main symptom associated with knee osteoarthritis. Recent clinical and pre-clinical studies have provided novel insights into the mechanisms that drive the pain associated with joint destruction. In this narrative review, we describe current knowledge regarding the changes in the peripheral and central nervous systems that occur during the progression of osteoarthritis and discuss how therapeutic interventions may provide pain relief.

Original languageEnglish (US)
Pages (from-to)318-326
Number of pages9
JournalCurrent Osteoporosis Reports
Volume13
Issue number5
DOIs
StatePublished - Oct 7 2015

Keywords

  • Animal models
  • Nerve growth factor
  • Osteoarthritis
  • Pain
  • Sensitization
  • Sodium channels

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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