TY - JOUR
T1 - The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV)
AU - for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study
AU - Yildirim, Cenk
AU - Garvie, Patricia A.
AU - Chernoff, Miriam
AU - Wilkins, Megan L.
AU - Patton, E. Doyle
AU - Williams, Paige L.
AU - Nichols, Sharon L.
AU - Yogev, Ram
AU - Sanders, Margaret Ann
AU - Malee, Kathleen
AU - Hunter, Scott
AU - Shearer, William
AU - Paul, Mary
AU - Cooper, Norma
AU - Harris, Lynnette
AU - Purswani, Murli
AU - Baig, Mahboobullah
AU - Cintron, Anna
AU - Navarro, Ana
AU - Garvie, Patricia
AU - Blood, James
AU - Burchett, Sandra
AU - Karthas, Nancy
AU - Kammerer, Betsy
AU - Wiznia, Andrew
AU - Burey, Marlene
AU - Nozyce, Molly
AU - Dieudonne, Arry
AU - Bettica, Linda
AU - Adubato, Susan
AU - Chen, Janet
AU - Bulkley, Maria Garcia
AU - Ivey, Latreaca
AU - Grant, Mitzie
AU - Knapp, Katherine
AU - Allison, Kim
AU - Wilkins, Megan
AU - Acevedo-Flores, Midnela
AU - Rios, Heida
AU - Olivera, Vivian
AU - Silio, Margarita
AU - Jones, Medea
AU - Sirois, Patricia
AU - Spector, Stephen
AU - Norris, Kim
AU - Nichols, Sharon
AU - McFarland, Elizabeth
AU - Katai, Alisa
AU - Dunn, Jennifer
AU - Paul, Suzanne
N1 - Funding Information:
The authors extend their gratitude to Kunjal Patel, DSc, MPH, Senior Research Scientist, Harvard T.H. Chan School of Public Health, Department of Epidemiology, for her valuable consultation to the statistical analyses.
Funding Information:
The Pediatric HIV/AIDS Cohort Study (PHACS) Memory and Executive Functioning substudy was supported by the National Institute of Mental Health (MH084794; PI: Sharon Nichols). Data analysis services were provided by the Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health (PI: Paige Williams); data management services were provided by Frontier Science and Technology Research Foundation (PI: Suzanne Siminski); and regulatory services and logistical support were provided by Westat, Inc. (PI: Julie Davidson). The Pediatric HIV/AIDS Cohort Study (PHACS) was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development with co-funding from the National Institute on Drug Abuse, the National Institute of Allergy and Infectious Diseases, the Office of AIDS Research, the National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke, the National Institute on Deafness and Other Communication Disorders, the National Heart Lung and Blood Institute, the National Institute of Dental and Craniofacial Research, and the National Institute on Alcohol Abuse and Alcoholism, through cooperative agreements with the Harvard University T.H. Chan School of Public Health (HD052102) (Principal Investigator: George Seage; Project Director: Julie Alperen) and the Tulane University School of Medicine (HD052104) (Principal Investigator: Russell Van Dyke; Co-Principal Investigators: Kenneth Rich, Ellen Chadwick; Project Director: Patrick Davis).
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.
AB - Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.
KW - ARV adherence
KW - Appointment adherence
KW - Pediatric HIV
KW - Pharmacy refill
KW - Self-report
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UR - http://www.scopus.com/inward/citedby.url?scp=85064226158&partnerID=8YFLogxK
U2 - 10.1007/s10461-019-02468-x
DO - 10.1007/s10461-019-02468-x
M3 - Article
C2 - 30929147
AN - SCOPUS:85064226158
SN - 1090-7165
VL - 23
SP - 2109
EP - 2120
JO - AIDS and behavior
JF - AIDS and behavior
IS - 8
ER -
