TY - JOUR
T1 - The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV)
AU - for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study
AU - Yildirim, Cenk
AU - Garvie, Patricia A.
AU - Chernoff, Miriam
AU - Wilkins, Megan L.
AU - Patton, E. Doyle
AU - Williams, Paige L.
AU - Nichols, Sharon L.
AU - Yogev, Ram
AU - Sanders, Margaret Ann
AU - Malee, Kathleen
AU - Hunter, Scott
AU - Shearer, William
AU - Paul, Mary
AU - Cooper, Norma
AU - Harris, Lynnette
AU - Purswani, Murli
AU - Baig, Mahboobullah
AU - Cintron, Anna
AU - Navarro, Ana
AU - Garvie, Patricia
AU - Blood, James
AU - Burchett, Sandra
AU - Karthas, Nancy
AU - Kammerer, Betsy
AU - Wiznia, Andrew
AU - Burey, Marlene
AU - Nozyce, Molly
AU - Dieudonne, Arry
AU - Bettica, Linda
AU - Adubato, Susan
AU - Chen, Janet
AU - Bulkley, Maria Garcia
AU - Ivey, Latreaca
AU - Grant, Mitzie
AU - Knapp, Katherine
AU - Allison, Kim
AU - Wilkins, Megan
AU - Acevedo-Flores, Midnela
AU - Rios, Heida
AU - Olivera, Vivian
AU - Silio, Margarita
AU - Jones, Medea
AU - Sirois, Patricia
AU - Spector, Stephen
AU - Norris, Kim
AU - Nichols, Sharon
AU - McFarland, Elizabeth
AU - Katai, Alisa
AU - Dunn, Jennifer
AU - Paul, Suzanne
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.
AB - Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.
KW - ARV adherence
KW - Appointment adherence
KW - Pediatric HIV
KW - Pharmacy refill
KW - Self-report
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U2 - 10.1007/s10461-019-02468-x
DO - 10.1007/s10461-019-02468-x
M3 - Article
C2 - 30929147
AN - SCOPUS:85064226158
SN - 1090-7165
VL - 23
SP - 2109
EP - 2120
JO - AIDS and behavior
JF - AIDS and behavior
IS - 8
ER -
