TY - JOUR
T1 - The role of platelet-activating factor in asthma
AU - Smith, L. J.
PY - 1991
Y1 - 1991
N2 - There is a large body of in vitro, animal, and now human data that provide strong support for PAF as being an important mediator of asthma and airway hyperreactivity. Unfortunately, there is little direct, unequivocal evidence that this is so. Direct evidence will come from studies that test the effectiveness of potent, nontoxic, PAF receptor antagonists in patients with asthma. Another issue that needs to be addressed is the mechanism by which PAF produces bronchoconstriction and, in particular, airway hyperreactivity. Studies exploring the effect of PAF on inflammatory cell populations and functions in the lung, on other mediators (i.e., leukotrienes), and on the nonadrenergic, noncholinergic nervous system in human subjects are needed. Finally, identification of the basis for the variable response to PAF in normal subjects and in patients with asthma should provide further insight into PAF's mechanism of action and the pathogenesis of asthma and airway hyperreactivity.
AB - There is a large body of in vitro, animal, and now human data that provide strong support for PAF as being an important mediator of asthma and airway hyperreactivity. Unfortunately, there is little direct, unequivocal evidence that this is so. Direct evidence will come from studies that test the effectiveness of potent, nontoxic, PAF receptor antagonists in patients with asthma. Another issue that needs to be addressed is the mechanism by which PAF produces bronchoconstriction and, in particular, airway hyperreactivity. Studies exploring the effect of PAF on inflammatory cell populations and functions in the lung, on other mediators (i.e., leukotrienes), and on the nonadrenergic, noncholinergic nervous system in human subjects are needed. Finally, identification of the basis for the variable response to PAF in normal subjects and in patients with asthma should provide further insight into PAF's mechanism of action and the pathogenesis of asthma and airway hyperreactivity.
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U2 - 10.1164/ajrccm/143.5_pt_2.s100
DO - 10.1164/ajrccm/143.5_pt_2.s100
M3 - Article
C2 - 2018248
AN - SCOPUS:0025830103
SN - 0003-0805
VL - 143
SP - S100-S102
JO - American Review of Respiratory Disease
JF - American Review of Respiratory Disease
IS - 5 II
ER -