The role of protective CD8+ T cells in resistance of BALB/c mice to Theiler's murine encephalomyelitis virus-induced demyelinating disease: Regulatory vs. lytic

Simone M. Nicholson, Lia M. Haynes, Carol L. Vanderlugt, Stephen D. Miller, Roger W. Melvold*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is an excellent model for human multiple sclerosis. Within the BALB/c strain, BALB/cAnNCr mice are susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice become susceptible when irradiated. Adoptive transfer of CD8+ splenic T cells from resistant BALB/cByJ donors protect irradiated BALB/cByJ, as well as BALB/cAnNCr recipients, from development of TMEV-IDD. Anti-TMEV CTL activities in BALB/cAnNCr, BALB/cByJ and irradiated BALB/cByJ mice are comparable. A population of splenic CD4+ T cells in BALB/cByJ donors has also been identified which can protect both susceptible BALB/cAnNCr and irradiated BALB/cByJ recipients from TMEV-IDD via adoptive transfer. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)136-146
Number of pages11
JournalJournal of Neuroimmunology
Volume98
Issue number2
DOIs
StatePublished - Aug 3 1999

Keywords

  • EAE/MS
  • Mouse
  • Neuroimmunology
  • T lymphocytes
  • TMEV

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'The role of protective CD8<sup>+</sup> T cells in resistance of BALB/c mice to Theiler's murine encephalomyelitis virus-induced demyelinating disease: Regulatory vs. lytic'. Together they form a unique fingerprint.

  • Cite this