The role of protective CD8+ T cells in resistance of BALB/c mice to Theiler's murine encephalomyelitis virus-induced demyelinating disease: Regulatory vs. lytic

Simone M. Nicholson; Lia M. Haynes; Carol L. Vanderlugt; Stephen D. Miller; Roger W. Melvold

doi:10.1016/S0165-5728(99)00090-9

The role of protective CD8⁺ T cells in resistance of BALB/c mice to Theiler's murine encephalomyelitis virus-induced demyelinating disease: Regulatory vs. lytic

Simone M. Nicholson, Lia M. Haynes, Carol L. Vanderlugt, Stephen D. Miller, Roger W. Melvold^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is an excellent model for human multiple sclerosis. Within the BALB/c strain, BALB/cAnNCr mice are susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice become susceptible when irradiated. Adoptive transfer of CD8⁺ splenic T cells from resistant BALB/cByJ donors protect irradiated BALB/cByJ, as well as BALB/cAnNCr recipients, from development of TMEV-IDD. Anti-TMEV CTL activities in BALB/cAnNCr, BALB/cByJ and irradiated BALB/cByJ mice are comparable. A population of splenic CD4⁺ T cells in BALB/cByJ donors has also been identified which can protect both susceptible BALB/cAnNCr and irradiated BALB/cByJ recipients from TMEV-IDD via adoptive transfer. Copyright (C) 1999 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	136-146
Number of pages	11
Journal	Journal of Neuroimmunology
Volume	98
Issue number	2
DOIs	https://doi.org/10.1016/S0165-5728(99)00090-9
State	Published - Aug 3 1999

Funding

This work was supported in part by grant NS23349 from the NIH.

Keywords

EAE/MS
Mouse
Neuroimmunology
T lymphocytes
TMEV

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0165-5728(99)00090-9

Cite this

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title = "The role of protective CD8+ T cells in resistance of BALB/c mice to Theiler's murine encephalomyelitis virus-induced demyelinating disease: Regulatory vs. lytic",

abstract = "Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is an excellent model for human multiple sclerosis. Within the BALB/c strain, BALB/cAnNCr mice are susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice become susceptible when irradiated. Adoptive transfer of CD8+ splenic T cells from resistant BALB/cByJ donors protect irradiated BALB/cByJ, as well as BALB/cAnNCr recipients, from development of TMEV-IDD. Anti-TMEV CTL activities in BALB/cAnNCr, BALB/cByJ and irradiated BALB/cByJ mice are comparable. A population of splenic CD4+ T cells in BALB/cByJ donors has also been identified which can protect both susceptible BALB/cAnNCr and irradiated BALB/cByJ recipients from TMEV-IDD via adoptive transfer. Copyright (C) 1999 Elsevier Science B.V.",

keywords = "EAE/MS, Mouse, Neuroimmunology, T lymphocytes, TMEV",

author = "Nicholson, {Simone M.} and Haynes, {Lia M.} and Vanderlugt, {Carol L.} and Miller, {Stephen D.} and Melvold, {Roger W.}",

note = "Funding Information: This work was supported in part by grant NS23349 from the NIH.",

year = "1999",

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AU - Haynes, Lia M.

AU - Vanderlugt, Carol L.

AU - Miller, Stephen D.

AU - Melvold, Roger W.

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N2 - Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is an excellent model for human multiple sclerosis. Within the BALB/c strain, BALB/cAnNCr mice are susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice become susceptible when irradiated. Adoptive transfer of CD8+ splenic T cells from resistant BALB/cByJ donors protect irradiated BALB/cByJ, as well as BALB/cAnNCr recipients, from development of TMEV-IDD. Anti-TMEV CTL activities in BALB/cAnNCr, BALB/cByJ and irradiated BALB/cByJ mice are comparable. A population of splenic CD4+ T cells in BALB/cByJ donors has also been identified which can protect both susceptible BALB/cAnNCr and irradiated BALB/cByJ recipients from TMEV-IDD via adoptive transfer. Copyright (C) 1999 Elsevier Science B.V.

AB - Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is an excellent model for human multiple sclerosis. Within the BALB/c strain, BALB/cAnNCr mice are susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice become susceptible when irradiated. Adoptive transfer of CD8+ splenic T cells from resistant BALB/cByJ donors protect irradiated BALB/cByJ, as well as BALB/cAnNCr recipients, from development of TMEV-IDD. Anti-TMEV CTL activities in BALB/cAnNCr, BALB/cByJ and irradiated BALB/cByJ mice are comparable. A population of splenic CD4+ T cells in BALB/cByJ donors has also been identified which can protect both susceptible BALB/cAnNCr and irradiated BALB/cByJ recipients from TMEV-IDD via adoptive transfer. Copyright (C) 1999 Elsevier Science B.V.

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