The Role of Screening for Asymptomatic Ocular Inflammation in Sarcoidosis

Jennifer Lee, Fatma Zaguia, Caroline Minkus, Anjum F. Koreishi, Andrea D. Birnbaum, Debra A. Goldstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: To determine the utility of routine screening ophthalmic exam in patients with systemic sarcoidosis and no history of uveitis. Methods: Prospective, single-center, observational study conducted at Northwestern University from October 11, 2012 to October 1, 2020 of new patients with biopsy-proven systemic sarcoidosis and no history of uveitis, referred by medical subspecialists for screening ophthalmic exam. Results: Forty-nine patients, with mean age of 51 ± 8.7 years, 59% female, 47% African American, 43% Caucasian, were enrolled. The majority (55%) had no ocular symptoms. The most common location of ocular involvement was the adnexa, in the form of conjunctival nodules (62%) and aqueous tear deficiency (23%). Intraocular inflammation was detected in 6 patients (13%); only 2 had active disease requiring treatment (4%). No asymptomatic patient had ocular involvement necessitating treatment. Conclusion: Screening exams are indicated in sarcoidosis patients with ocular symptoms. No benefit of screening was demonstrated in asymptomatic patients.

Original languageEnglish (US)
Pages (from-to)1936-1939
Number of pages4
JournalOcular Immunology and Inflammation
Issue number7-8
StatePublished - 2022


  • Sarcoidosis
  • inflammatory eye disease
  • screening
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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