TY - JOUR
T1 - The role of sentinel lymph node biopsy in Paget's disease of the breast
AU - Sukumvanich, P.
AU - Bentrem, D. J.
AU - Cody, H. S.
AU - Brogi, E.
AU - Fey, J. V.
AU - Borgen, P. I.
AU - Gemignani, M. L.
PY - 2007/3
Y1 - 2007/3
N2 - Background: Sentinel lymph node (SLN) biopsy has become a standard of care for axillary lymph node staging in breast cancer and appears suitable for virtually all patients with clinically node-negative (cN0) invasive disease. However, its role in Paget's disease of the breast, a condition in which invasion may or may not be present, remains undefined. Methods: Among 7,083 consecutive SLN biopsy procedures, we retrospectively identified 39 patients with Paget's disease of the breast. Nineteen patients had no associated clinical/ radiographic features ("Paget's only"), and 20 patients had associated clinical/radiographic findings ("Paget's with findings"). Results: The mean ages for the Paget's alone and with findings groups were 63.6 and 49.6 years, respectively. The use of breast conservation therapy was 32% in the Paget's alone group and 10% in the Paget's with findings group. Invasive carcinoma was found in 27% of patients in the Paget's alone group and 55% of patients in the Paget's with findings group. The success rate of SLN biopsy was 98%, and the mean number of SLNs removed was 3 in both groups. In the entire cohort of Paget's disease, 28% (11/39) of the patients had positive SLNs (11%, Paget's alone; 45%, Paget's with findings). Conclusion: In our "Paget's only" cohort, invasive cancer was found in 27% of cases and positive SLNs in 11%. SLN biopsy should be considered in all patients with Paget's disease of the breast, whether associated clinical/radiographic findings are present. Published by Springer Science+Business Media, Inc.
AB - Background: Sentinel lymph node (SLN) biopsy has become a standard of care for axillary lymph node staging in breast cancer and appears suitable for virtually all patients with clinically node-negative (cN0) invasive disease. However, its role in Paget's disease of the breast, a condition in which invasion may or may not be present, remains undefined. Methods: Among 7,083 consecutive SLN biopsy procedures, we retrospectively identified 39 patients with Paget's disease of the breast. Nineteen patients had no associated clinical/ radiographic features ("Paget's only"), and 20 patients had associated clinical/radiographic findings ("Paget's with findings"). Results: The mean ages for the Paget's alone and with findings groups were 63.6 and 49.6 years, respectively. The use of breast conservation therapy was 32% in the Paget's alone group and 10% in the Paget's with findings group. Invasive carcinoma was found in 27% of patients in the Paget's alone group and 55% of patients in the Paget's with findings group. The success rate of SLN biopsy was 98%, and the mean number of SLNs removed was 3 in both groups. In the entire cohort of Paget's disease, 28% (11/39) of the patients had positive SLNs (11%, Paget's alone; 45%, Paget's with findings). Conclusion: In our "Paget's only" cohort, invasive cancer was found in 27% of cases and positive SLNs in 11%. SLN biopsy should be considered in all patients with Paget's disease of the breast, whether associated clinical/radiographic findings are present. Published by Springer Science+Business Media, Inc.
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U2 - 10.1245/s10434-006-9056-2
DO - 10.1245/s10434-006-9056-2
M3 - Article
C2 - 17195914
AN - SCOPUS:34250167646
SN - 1068-9265
VL - 14
SP - 1020
EP - 1023
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 3
ER -