Abstract
During the last several years, sphingolipids have been identified as a source of important signaling molecules. Particularly, the understanding of the distinct biological roles of ceramide, sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P) and lyso-sphingomyelin in the regulation of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking has rapidly expanded. Additional studies have elucidated the biological roles of sphingolipids in maintaining a homeostatic environment in cells, as well as in regulating numerous cellular responses to environmental stimuli. This review focuses on the role of S1P and C1P in maintaining Ca2+ homeostasis. By studying changes in the metabolism of S1P and C1P in pathological conditions, it is hoped that altered sphingolipid- metabolizing enzymes and their metabolites can be used as therapeutic targets.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1192-1205 |
| Number of pages | 14 |
| Journal | Current Opinion in Investigational Drugs |
| Volume | 9 |
| Issue number | 11 |
| State | Published - Nov 1 2008 |
Keywords
- Calcium
- Ceramide kinase
- Ceramide-1-phosphate
- Sphingosine kinase
- Sphingosine-1-phosphate
- Therapeutic target
- Transient potential channel
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery