The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis

V. Hinkovska-Galcheva*, S. M. VanWay, T. P. Shanley, R. G. Kunkel

*Corresponding author for this work

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

During the last several years, sphingolipids have been identified as a source of important signaling molecules. Particularly, the understanding of the distinct biological roles of ceramide, sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P) and lyso-sphingomyelin in the regulation of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking has rapidly expanded. Additional studies have elucidated the biological roles of sphingolipids in maintaining a homeostatic environment in cells, as well as in regulating numerous cellular responses to environmental stimuli. This review focuses on the role of S1P and C1P in maintaining Ca2+ homeostasis. By studying changes in the metabolism of S1P and C1P in pathological conditions, it is hoped that altered sphingolipid- metabolizing enzymes and their metabolites can be used as therapeutic targets.

Original languageEnglish (US)
Pages (from-to)1192-1205
Number of pages14
JournalCurrent Opinion in Investigational Drugs
Volume9
Issue number11
StatePublished - Nov 1 2008

Keywords

  • Calcium
  • Ceramide kinase
  • Ceramide-1-phosphate
  • Sphingosine kinase
  • Sphingosine-1-phosphate
  • Therapeutic target
  • Transient potential channel

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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