The role of STAT3 in tumor-mediated immune suppression

Sherise D. Ferguson*, Visish M. Srinivasan, Amy B. Heimberger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.

Original languageEnglish (US)
Pages (from-to)385-394
Number of pages10
JournalJournal of Neuro-Oncology
Issue number3
StatePublished - Jul 23 2015
Externally publishedYes


  • Glioblastoma
  • Immune suppression
  • STAT3

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research


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