The Role of Surface in the Pathogenesis and Treatment of COVID-19

Andrew C. Retzinger; Gregory S. Retzinger

doi:10.3390/covid1020040

The Role of Surface in the Pathogenesis and Treatment of COVID-19

Andrew C. Retzinger^*, Gregory S. Retzinger

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, an inverse relationship between incidence of COVID-19 and seasonal aerosolization of mold spores was demonstrated. Analyses of that relationship suggested mold spores compete with SARS-CoV-2 virions for a receptor on the pulmonary epithelial surface. By inference, the operative receptor was proposed to be Toll-like receptor 4, with surface-localized virions being responsible for symptomatology. In this report, the pathogenesis of COVID-19 is further developed, with a focus on a role for surfactant protein D in the process. This developed proposal provides both mechanistic understanding and suggested treatments of COVID-19.

Original language	English (US)
Pages (from-to)	465-471
Number of pages	7
Journal	COVID
Volume	1
Issue number	2
DOIs	https://doi.org/10.3390/covid1020040
State	Published - Oct 2021

Keywords

COVID-19
COVID-19 therapy
fibrin(ogen)
SARS-CoV-2
surface
surfactant protein D (SP-D)
toll-like receptor 4 (TLR4)

ASJC Scopus subject areas

Immunology and Microbiology (miscellaneous)
Medicine (miscellaneous)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/covid1020040

Cite this

@article{6c464807688c46fcbdcc288c4cc3577a,

title = "The Role of Surface in the Pathogenesis and Treatment of COVID-19",

abstract = "Recently, an inverse relationship between incidence of COVID-19 and seasonal aerosolization of mold spores was demonstrated. Analyses of that relationship suggested mold spores compete with SARS-CoV-2 virions for a receptor on the pulmonary epithelial surface. By inference, the operative receptor was proposed to be Toll-like receptor 4, with surface-localized virions being responsible for symptomatology. In this report, the pathogenesis of COVID-19 is further developed, with a focus on a role for surfactant protein D in the process. This developed proposal provides both mechanistic understanding and suggested treatments of COVID-19.",

keywords = "COVID-19, COVID-19 therapy, fibrin(ogen), SARS-CoV-2, surface, surfactant protein D (SP-D), toll-like receptor 4 (TLR4)",

author = "Retzinger, {Andrew C.} and Retzinger, {Gregory S.}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors.",

year = "2021",

month = oct,

doi = "10.3390/covid1020040",

language = "English (US)",

volume = "1",

pages = "465--471",

journal = "COVID",

issn = "2673-8112",

number = "2",

}

TY - JOUR

T1 - The Role of Surface in the Pathogenesis and Treatment of COVID-19

AU - Retzinger, Andrew C.

AU - Retzinger, Gregory S.

PY - 2021/10

Y1 - 2021/10

N2 - Recently, an inverse relationship between incidence of COVID-19 and seasonal aerosolization of mold spores was demonstrated. Analyses of that relationship suggested mold spores compete with SARS-CoV-2 virions for a receptor on the pulmonary epithelial surface. By inference, the operative receptor was proposed to be Toll-like receptor 4, with surface-localized virions being responsible for symptomatology. In this report, the pathogenesis of COVID-19 is further developed, with a focus on a role for surfactant protein D in the process. This developed proposal provides both mechanistic understanding and suggested treatments of COVID-19.

AB - Recently, an inverse relationship between incidence of COVID-19 and seasonal aerosolization of mold spores was demonstrated. Analyses of that relationship suggested mold spores compete with SARS-CoV-2 virions for a receptor on the pulmonary epithelial surface. By inference, the operative receptor was proposed to be Toll-like receptor 4, with surface-localized virions being responsible for symptomatology. In this report, the pathogenesis of COVID-19 is further developed, with a focus on a role for surfactant protein D in the process. This developed proposal provides both mechanistic understanding and suggested treatments of COVID-19.

KW - COVID-19

KW - COVID-19 therapy

KW - fibrin(ogen)

KW - SARS-CoV-2

KW - surface

KW - surfactant protein D (SP-D)

KW - toll-like receptor 4 (TLR4)

UR - http://www.scopus.com/inward/record.url?scp=85191147929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85191147929&partnerID=8YFLogxK

U2 - 10.3390/covid1020040

DO - 10.3390/covid1020040

M3 - Article

AN - SCOPUS:85191147929

SN - 2673-8112

VL - 1

SP - 465

EP - 471

JO - COVID

JF - COVID

IS - 2

ER -

The Role of Surface in the Pathogenesis and Treatment of COVID-19

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this