The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

Yvonne C. Lee; Nicholas J. Nassikas; Daniel J. Clauw

doi:10.1186/ar3306

The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

Yvonne C. Lee^*, Nicholas J. Nassikas, Daniel J. Clauw

^*Corresponding author for this work

Medicine, Rheumatology Division

Research output: Contribution to journal › Review article › peer-review

310 Scopus citations

Abstract

Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have also noted alterations in central pain processing in osteoarthritis, and some data, including the observation of widespread pain sensitivity, suggest that central pain-processing defects may alter the pain response in rheumatoid arthritis patients. When central pain is identified, different classes of analgesics (for example, serotonin-norepinephrine reuptake inhibitors, α₂δ ligands) may be more effective than drugs that treat peripheral or nociceptive pain (for example, nonsteroidal anti-inflammatory drugs and opioids).

Original language	English (US)
Article number	211
Journal	Arthritis Research and Therapy
Volume	13
Issue number	2
DOIs	https://doi.org/10.1186/ar3306
State	Published - Apr 28 2011

Funding

Grant support was received from NIH/NIAMS grant AR057578. The funding body played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

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10.1186/ar3306

Cite this

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abstract = "Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have also noted alterations in central pain processing in osteoarthritis, and some data, including the observation of widespread pain sensitivity, suggest that central pain-processing defects may alter the pain response in rheumatoid arthritis patients. When central pain is identified, different classes of analgesics (for example, serotonin-norepinephrine reuptake inhibitors, α2δ ligands) may be more effective than drugs that treat peripheral or nociceptive pain (for example, nonsteroidal anti-inflammatory drugs and opioids).",

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The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

Abstract

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