The Role of the Extracellular Matrix in Ovarian Follicle Development

Teresa K. Woodruff*, Lonnie D. Shea

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Regulation of ovarian follicle development depends on endocrine- and paracrine-acting hormones, the 3-dimensional architecture of the follicle, and the physical rigidity of the surrounding tissue. These 3 forces are integrated throughout the life cycle of the follicle to ensure appropriate hormone secretion, differentiation of the somatic cells, and maturation of the oocyte. The process of in-follicle maturation provides a new tool for understanding ovarian follicle development under the influence of these factors.

Original languageEnglish (US)
Pages (from-to)6-10
Number of pages5
JournalReproductive Sciences
Issue number8_suppl
StatePublished - Dec 1 2007


  • Follicle
  • alginate
  • in-follicle maturation.

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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