The role of the innate immune system in sepsis

Nina Censoplano; Conrad L. Epting; Bria M. Coates

doi:10.1016/j.cpem.2014.04.007

The role of the innate immune system in sepsis

Nina Censoplano, Conrad L. Epting, Bria M. Coates^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Sepsis is a clinical syndrome characterized by activation of the host inflammatory system in response to infection. The initial phase, manifested by shock, fever, and hypermetabolism, is largely secondary to a hyperinflammatory state and is responsible for the classic signs and symptoms of early sepsis. This review focuses on the early events after infection, offering an overview of the innate immune response in the sepsis syndrome, and concludes with a discussion of immune-targeted therapies.

Original language	English (US)
Pages (from-to)	169-176
Number of pages	8
Journal	Clinical pediatric emergency medicine
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/j.cpem.2014.04.007
State	Published - Jun 2014

Keywords

Chemokines
Complement
Cytokines
Endothelium
Immunotherapy
Innate immune system
Pattern recognition receptors
Sepsis
Toll-like receptors

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Emergency Medicine

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10.1016/j.cpem.2014.04.007

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title = "The role of the innate immune system in sepsis",

abstract = "Sepsis is a clinical syndrome characterized by activation of the host inflammatory system in response to infection. The initial phase, manifested by shock, fever, and hypermetabolism, is largely secondary to a hyperinflammatory state and is responsible for the classic signs and symptoms of early sepsis. This review focuses on the early events after infection, offering an overview of the innate immune response in the sepsis syndrome, and concludes with a discussion of immune-targeted therapies.",

keywords = "Chemokines, Complement, Cytokines, Endothelium, Immunotherapy, Innate immune system, Pattern recognition receptors, Sepsis, Toll-like receptors",

author = "Nina Censoplano and Epting, {Conrad L.} and Coates, {Bria M.}",

year = "2014",

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AU - Censoplano, Nina

AU - Epting, Conrad L.

AU - Coates, Bria M.

PY - 2014/6

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N2 - Sepsis is a clinical syndrome characterized by activation of the host inflammatory system in response to infection. The initial phase, manifested by shock, fever, and hypermetabolism, is largely secondary to a hyperinflammatory state and is responsible for the classic signs and symptoms of early sepsis. This review focuses on the early events after infection, offering an overview of the innate immune response in the sepsis syndrome, and concludes with a discussion of immune-targeted therapies.

AB - Sepsis is a clinical syndrome characterized by activation of the host inflammatory system in response to infection. The initial phase, manifested by shock, fever, and hypermetabolism, is largely secondary to a hyperinflammatory state and is responsible for the classic signs and symptoms of early sepsis. This review focuses on the early events after infection, offering an overview of the innate immune response in the sepsis syndrome, and concludes with a discussion of immune-targeted therapies.

KW - Chemokines

KW - Complement

KW - Cytokines

KW - Endothelium

KW - Immunotherapy

KW - Innate immune system

KW - Pattern recognition receptors

KW - Sepsis

KW - Toll-like receptors

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SP - 169

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JO - Clinical pediatric emergency medicine

JF - Clinical pediatric emergency medicine

IS - 2

ER -

The role of the innate immune system in sepsis

Abstract

Keywords

ASJC Scopus subject areas

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