The role of the innate immune system in sepsis

Nina Censoplano, Conrad L Epting, Bria Coates*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Sepsis is a clinical syndrome characterized by activation of the host inflammatory system in response to infection. The initial phase, manifested by shock, fever, and hypermetabolism, is largely secondary to a hyperinflammatory state and is responsible for the classic signs and symptoms of early sepsis. This review focuses on the early events after infection, offering an overview of the innate immune response in the sepsis syndrome, and concludes with a discussion of immune-targeted therapies.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalClinical Pediatric Emergency Medicine
Volume15
Issue number2
DOIs
StatePublished - Jan 1 2014

Keywords

  • Chemokines
  • Complement
  • Cytokines
  • Endothelium
  • Immunotherapy
  • Innate immune system
  • Pattern recognition receptors
  • Sepsis
  • Toll-like receptors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine

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