Abstract
The expression of the metalloproteinase stromelysin correlates with the progression of chemically induced squamous cell carcinomas. We demonstrate that the expression of activated stromelysin in papilloma-derived cells enhances in vitro cell invasion. We also demonstrate that the Ha-ras oncogene induces the transcription of the stromelysin gene through an AP-1 dependent pathway. The hypothesis is that alterations in oncogenes and suppressor genes influence stromelysin expression and thus influence subsequent steps of tumor invasion and metastasis.
Original language | English (US) |
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Pages (from-to) | 157-162 |
Number of pages | 6 |
Journal | American Journal of the Medical Sciences |
Volume | 302 |
Issue number | 3 |
DOIs | |
State | Published - 1991 |
Keywords
- invasion
- metalloproteinase
- progression
- ras
- stromelysin
ASJC Scopus subject areas
- Medicine(all)