Abstract
The expression of the metalloproteinase stromelysin correlates with the progression of chemically induced squamous cell carcinomas. We demonstrate that the expression of activated stromelysin in papilloma-derived cells enhances in vitro cell invasion. We also demonstrate that the Ha-ras oncogene induces the transcription of the stromelysin gene through an AP-1 dependent pathway. The hypothesis is that alterations in oncogenes and suppressor genes influence stromelysin expression and thus influence subsequent steps of tumor invasion and metastasis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 157-162 |
| Number of pages | 6 |
| Journal | American Journal of the Medical Sciences |
| Volume | 302 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1991 |
Funding
This research was supported by the NIH (CA46843 and CA48799 to L.M.M.J and the ACS (JFRA-J92 to L.M.M.J, and a private donation from Mr. and Mrs. Eric T. Staniek (to M.J.C.H.J.
Keywords
- invasion
- metalloproteinase
- progression
- ras
- stromelysin
ASJC Scopus subject areas
- General Medicine
