Abstract
Measurements and modeling of intraretinal [H]+ can provide information about the retinal microenvironment in disease. Here, the concentration of H+ in the outer retina was measured to understand the role of H+ in diabetic retinopathy, and simulations of H+ gradients were performed to understand the possible contributions of changing pH to the pathogenesis of age-related macular degeneration (ARMD). Intraretinal pH profiles were recorded in anesthetized diabetic cats using pH sensitive microelectrodes. During diabetes, there were changes in the inner retinal H+ gradient in some areas of the retina. Some pH profiles showed decreased H+ production in the outer retina. The pH changes in ARMD were investigated using simulations of a four-layer diffusion model. The effects of variable drusen size and choroidal blood flow (ChBF) were investigated. The pH profiles showed that there was increased H+ concentration in the outer retina with the introduction of drusen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2133-2134 |
| Number of pages | 2 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 3 |
| State | Published - Dec 1 2002 |
Keywords
- Age-related macular degeneration
- pH measurements
- Retinal microenvironment
ASJC Scopus subject areas
- Bioengineering
