The role of the pH microenvironment in retinal diseases

Robert A Linsenmeier*, Ewa Budzynski, Christina K. Chung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Measurements and modeling of intraretinal [H]+ can provide information about the retinal microenvironment in disease. Here, the concentration of H+ in the outer retina was measured to understand the role of H+ in diabetic retinopathy, and simulations of H+ gradients were performed to understand the possible contributions of changing pH to the pathogenesis of age-related macular degeneration (ARMD). Intraretinal pH profiles were recorded in anesthetized diabetic cats using pH sensitive microelectrodes. During diabetes, there were changes in the inner retinal H+ gradient in some areas of the retina. Some pH profiles showed decreased H+ production in the outer retina. The pH changes in ARMD were investigated using simulations of a four-layer diffusion model. The effects of variable drusen size and choroidal blood flow (ChBF) were investigated. The pH profiles showed that there was increased H+ concentration in the outer retina with the introduction of drusen.

Original languageEnglish (US)
Pages (from-to)2133-2134
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume3
StatePublished - Dec 1 2002

Keywords

  • Age-related macular degeneration
  • pH measurements
  • Retinal microenvironment

ASJC Scopus subject areas

  • Bioengineering

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