The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size

C. M. Ackerman; L. P. Lowe; H. Lee; F. Chen; E. Hughes; P. Cholod; A. R. Dyer; M. G. Hayes; B. E. Metzger; W. L. Lowe; Margrit Urbanek

doi:10.1210/jc.2009-2718

The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size

C. M. Ackerman, L. P. Lowe, H. Lee, F. Chen, E. Hughes, P. Cholod, A. R. Dyer, M. G. Hayes, B. E. Metzger, W. L. Lowe, Margrit Urbanek^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Context: The high incidence of insulin resistance, type 2 diabetes, and metabolic syndrome in Western societies and their impact on quality of life emphasize the importance of identifying underlying susceptibility loci for metabolic diseases. The polycystic ovary syndrome (PCOS) susceptibility locus D19S884 allele 8 (A8) is associated with measures of insulin resistance, β-cell dysfunction, and other metabolic phenotypes in PCOS families. We now investigate the role of D19S884 A8 in pregnancy. Objective: Using the multiethnic Hyperglycemia and Adverse Pregnancy Outcome cohort, we assessed the associations of D19S884 A8 with measures of maternal glycemia and fetal size. Design: We tested for association of maternal D19S884 A8 with maternal outcomes (fasting, 1-h, and2-h plasma glucose, and fasting and 1-h C-peptide fromanoral glucose tolerance test)andfetal and maternal D19S884 A8 with fetal outcomes (birth weight, length, head circumference, sum of skin folds, fat mass, cord C-peptide, and 2-h neonatal plasma glucose). Subjects: We analyzed 4424 Caucasian mothers and 3347 offspring of northern European ancestry, 1957 Thai mothers and 2089 offspring from Bangkok, 1208 Afro-Caribbean mothers and 1209 offspring from Barbados, and 774 Hispanic mothers and 762 offspring from Bellflower, California. Results: After adjusting for confounding variables and multiple testing, neither maternal nor fetal D19S884 A8 showed significant evidence for association with any of the outcomes tested. Conclusions: The PCOS susceptibility locus, D19S884 A8, is not a major factor contributing to glycemia during pregnancy or fetal size in a general obstetric population.

Original language	English (US)
Pages (from-to)	3242-3250
Number of pages	9
Journal	Journal of clinical endocrinology and metabolism
Volume	95
Issue number	7
DOIs	https://doi.org/10.1210/jc.2009-2718
State	Published - Jul 2010

Funding

This work was supported by National Institutes of Health Grant P50 HD44405 and by Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarships Program award PGS-D. This work was also supported by Grants R01 DK067459 and U01 HG004415 from the National Institute of Diabetes, Digestive, and Kidney Diseases and the National Human Genome Research Institute . The HAPO study was funded by Grants R01-HD34242 and R01-HD34243 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institute of Diabetes and Digestive and Kidney Diseases, and by the American Diabetes Association . Members of the HAPO Study Cooperative Research Group are listed in the appendix of Ref. 21 .

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jc.2009-2718

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Ackerman, C. M., Lowe, L. P., Lee, H., Chen, F., Hughes, E., Cholod, P., Dyer, A. R., Hayes, M. G., Metzger, B. E., Lowe, W. L., & Urbanek, M. (2010). The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size. Journal of clinical endocrinology and metabolism, 95(7), 3242-3250. https://doi.org/10.1210/jc.2009-2718

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title = "The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size",

abstract = "Context: The high incidence of insulin resistance, type 2 diabetes, and metabolic syndrome in Western societies and their impact on quality of life emphasize the importance of identifying underlying susceptibility loci for metabolic diseases. The polycystic ovary syndrome (PCOS) susceptibility locus D19S884 allele 8 (A8) is associated with measures of insulin resistance, β-cell dysfunction, and other metabolic phenotypes in PCOS families. We now investigate the role of D19S884 A8 in pregnancy. Objective: Using the multiethnic Hyperglycemia and Adverse Pregnancy Outcome cohort, we assessed the associations of D19S884 A8 with measures of maternal glycemia and fetal size. Design: We tested for association of maternal D19S884 A8 with maternal outcomes (fasting, 1-h, and2-h plasma glucose, and fasting and 1-h C-peptide fromanoral glucose tolerance test)andfetal and maternal D19S884 A8 with fetal outcomes (birth weight, length, head circumference, sum of skin folds, fat mass, cord C-peptide, and 2-h neonatal plasma glucose). Subjects: We analyzed 4424 Caucasian mothers and 3347 offspring of northern European ancestry, 1957 Thai mothers and 2089 offspring from Bangkok, 1208 Afro-Caribbean mothers and 1209 offspring from Barbados, and 774 Hispanic mothers and 762 offspring from Bellflower, California. Results: After adjusting for confounding variables and multiple testing, neither maternal nor fetal D19S884 A8 showed significant evidence for association with any of the outcomes tested. Conclusions: The PCOS susceptibility locus, D19S884 A8, is not a major factor contributing to glycemia during pregnancy or fetal size in a general obstetric population.",

author = "Ackerman, {C. M.} and Lowe, {L. P.} and H. Lee and F. Chen and E. Hughes and P. Cholod and Dyer, {A. R.} and Hayes, {M. G.} and Metzger, {B. E.} and Lowe, {W. L.} and Margrit Urbanek",

note = "Funding Information: This work was supported by National Institutes of Health Grant P50 HD44405 and by Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarships Program award PGS-D. This work was also supported by Grants R01 DK067459 and U01 HG004415 from the National Institute of Diabetes, Digestive, and Kidney Diseases and the National Human Genome Research Institute . The HAPO study was funded by Grants R01-HD34242 and R01-HD34243 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institute of Diabetes and Digestive and Kidney Diseases, and by the American Diabetes Association . Members of the HAPO Study Cooperative Research Group are listed in the appendix of Ref. 21 . ",

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T1 - The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size

AU - Ackerman, C. M.

AU - Lowe, L. P.

AU - Lee, H.

AU - Chen, F.

AU - Hughes, E.

AU - Cholod, P.

AU - Dyer, A. R.

AU - Hayes, M. G.

AU - Metzger, B. E.

AU - Lowe, W. L.

AU - Urbanek, Margrit

N1 - Funding Information: This work was supported by National Institutes of Health Grant P50 HD44405 and by Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarships Program award PGS-D. This work was also supported by Grants R01 DK067459 and U01 HG004415 from the National Institute of Diabetes, Digestive, and Kidney Diseases and the National Human Genome Research Institute . The HAPO study was funded by Grants R01-HD34242 and R01-HD34243 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institute of Diabetes and Digestive and Kidney Diseases, and by the American Diabetes Association . Members of the HAPO Study Cooperative Research Group are listed in the appendix of Ref. 21 .

PY - 2010/7

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N2 - Context: The high incidence of insulin resistance, type 2 diabetes, and metabolic syndrome in Western societies and their impact on quality of life emphasize the importance of identifying underlying susceptibility loci for metabolic diseases. The polycystic ovary syndrome (PCOS) susceptibility locus D19S884 allele 8 (A8) is associated with measures of insulin resistance, β-cell dysfunction, and other metabolic phenotypes in PCOS families. We now investigate the role of D19S884 A8 in pregnancy. Objective: Using the multiethnic Hyperglycemia and Adverse Pregnancy Outcome cohort, we assessed the associations of D19S884 A8 with measures of maternal glycemia and fetal size. Design: We tested for association of maternal D19S884 A8 with maternal outcomes (fasting, 1-h, and2-h plasma glucose, and fasting and 1-h C-peptide fromanoral glucose tolerance test)andfetal and maternal D19S884 A8 with fetal outcomes (birth weight, length, head circumference, sum of skin folds, fat mass, cord C-peptide, and 2-h neonatal plasma glucose). Subjects: We analyzed 4424 Caucasian mothers and 3347 offspring of northern European ancestry, 1957 Thai mothers and 2089 offspring from Bangkok, 1208 Afro-Caribbean mothers and 1209 offspring from Barbados, and 774 Hispanic mothers and 762 offspring from Bellflower, California. Results: After adjusting for confounding variables and multiple testing, neither maternal nor fetal D19S884 A8 showed significant evidence for association with any of the outcomes tested. Conclusions: The PCOS susceptibility locus, D19S884 A8, is not a major factor contributing to glycemia during pregnancy or fetal size in a general obstetric population.

AB - Context: The high incidence of insulin resistance, type 2 diabetes, and metabolic syndrome in Western societies and their impact on quality of life emphasize the importance of identifying underlying susceptibility loci for metabolic diseases. The polycystic ovary syndrome (PCOS) susceptibility locus D19S884 allele 8 (A8) is associated with measures of insulin resistance, β-cell dysfunction, and other metabolic phenotypes in PCOS families. We now investigate the role of D19S884 A8 in pregnancy. Objective: Using the multiethnic Hyperglycemia and Adverse Pregnancy Outcome cohort, we assessed the associations of D19S884 A8 with measures of maternal glycemia and fetal size. Design: We tested for association of maternal D19S884 A8 with maternal outcomes (fasting, 1-h, and2-h plasma glucose, and fasting and 1-h C-peptide fromanoral glucose tolerance test)andfetal and maternal D19S884 A8 with fetal outcomes (birth weight, length, head circumference, sum of skin folds, fat mass, cord C-peptide, and 2-h neonatal plasma glucose). Subjects: We analyzed 4424 Caucasian mothers and 3347 offspring of northern European ancestry, 1957 Thai mothers and 2089 offspring from Bangkok, 1208 Afro-Caribbean mothers and 1209 offspring from Barbados, and 774 Hispanic mothers and 762 offspring from Bellflower, California. Results: After adjusting for confounding variables and multiple testing, neither maternal nor fetal D19S884 A8 showed significant evidence for association with any of the outcomes tested. Conclusions: The PCOS susceptibility locus, D19S884 A8, is not a major factor contributing to glycemia during pregnancy or fetal size in a general obstetric population.

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The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size

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