The Role of Tregs in Glioma-Mediated Immunosuppression: Potential Target for Intervention

William Humphries; Jun Wei; John H. Sampson; Amy B. Heimberger

doi:10.1016/j.nec.2009.08.012

The Role of Tregs in Glioma-Mediated Immunosuppression: Potential Target for Intervention

William Humphries, Jun Wei, John H. Sampson, Amy B. Heimberger^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

The role of regulatory T cells (Tregs) in mediating immune suppression of anti-tumor immune responses is increasingly appreciated in patients with malignancies-especially within the malignant glioma patient population. This article discuss the role and prognostic significance of Tregs within glioma patients and delineates potential approaches for their inhibition that can be used alone or in combination with other immune therapeutics in clinical trials and in the clinical settings of recurrent or residual disease.

Original language	English (US)
Pages (from-to)	125-137
Number of pages	13
Journal	Neurosurgery clinics of North America
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.nec.2009.08.012
State	Published - Jan 2010
Externally published	Yes

Funding

Keywords

Central nervous system
Glioblastoma multiforme
Immunotherapy
Prognosis
Regulatory T cells
Vaccine

ASJC Scopus subject areas

Clinical Neurology
Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nec.2009.08.012

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title = "The Role of Tregs in Glioma-Mediated Immunosuppression: Potential Target for Intervention",

abstract = "The role of regulatory T cells (Tregs) in mediating immune suppression of anti-tumor immune responses is increasingly appreciated in patients with malignancies-especially within the malignant glioma patient population. This article discuss the role and prognostic significance of Tregs within glioma patients and delineates potential approaches for their inhibition that can be used alone or in combination with other immune therapeutics in clinical trials and in the clinical settings of recurrent or residual disease.",

keywords = "Central nervous system, Glioblastoma multiforme, Immunotherapy, Prognosis, Regulatory T cells, Vaccine",

author = "William Humphries and Jun Wei and Sampson, {John H.} and Heimberger, {Amy B.}",

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doi = "10.1016/j.nec.2009.08.012",

language = "English (US)",

volume = "21",

pages = "125--137",

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T1 - The Role of Tregs in Glioma-Mediated Immunosuppression

T2 - Potential Target for Intervention

AU - Humphries, William

AU - Wei, Jun

AU - Sampson, John H.

AU - Heimberger, Amy B.

PY - 2010/1

Y1 - 2010/1

N2 - The role of regulatory T cells (Tregs) in mediating immune suppression of anti-tumor immune responses is increasingly appreciated in patients with malignancies-especially within the malignant glioma patient population. This article discuss the role and prognostic significance of Tregs within glioma patients and delineates potential approaches for their inhibition that can be used alone or in combination with other immune therapeutics in clinical trials and in the clinical settings of recurrent or residual disease.

AB - The role of regulatory T cells (Tregs) in mediating immune suppression of anti-tumor immune responses is increasingly appreciated in patients with malignancies-especially within the malignant glioma patient population. This article discuss the role and prognostic significance of Tregs within glioma patients and delineates potential approaches for their inhibition that can be used alone or in combination with other immune therapeutics in clinical trials and in the clinical settings of recurrent or residual disease.

KW - Central nervous system

KW - Glioblastoma multiforme

KW - Immunotherapy

KW - Prognosis

KW - Regulatory T cells

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=70450176686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70450176686&partnerID=8YFLogxK

U2 - 10.1016/j.nec.2009.08.012

DO - 10.1016/j.nec.2009.08.012

M3 - Review article

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AN - SCOPUS:70450176686

SN - 1042-3680

VL - 21

SP - 125

EP - 137

JO - Neurosurgery clinics of North America

JF - Neurosurgery clinics of North America

IS - 1

ER -

The Role of Tregs in Glioma-Mediated Immunosuppression: Potential Target for Intervention

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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