The Role of Tregs in Glioma-Mediated Immunosuppression: Potential Target for Intervention

William Humphries, Jun Wei, John H. Sampson, Amy B. Heimberger*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

The role of regulatory T cells (Tregs) in mediating immune suppression of anti-tumor immune responses is increasingly appreciated in patients with malignancies-especially within the malignant glioma patient population. This article discuss the role and prognostic significance of Tregs within glioma patients and delineates potential approaches for their inhibition that can be used alone or in combination with other immune therapeutics in clinical trials and in the clinical settings of recurrent or residual disease.

Original languageEnglish (US)
Pages (from-to)125-137
Number of pages13
JournalNeurosurgery clinics of North America
Volume21
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Central nervous system
  • Glioblastoma multiforme
  • Immunotherapy
  • Prognosis
  • Regulatory T cells
  • Vaccine

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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