The role of voltage-sensitive dendritic conductances in generating bistable firing patterns in motoneurons

C. J. Heckman*, Robert H. Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Motoneurons receive a dense innervation from fibers that descend from the brainstem and release the monoamines serotonin and noradrenalin. When monoamines are present, moroneurons can produce plateau potentials, which are sustained depolarizations that outlast a brief excitatory input. During voltage clamp, steady monosynaptic input from Ia afferents produced a current that persisted after the Ia input ceased. The likely origin of this current was in dendritic regions, where plateau potential channels were probably activated due to the lack of voltage clamp control during the synaptic input. The functional significance of these data is discussed.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalJournal of Physiology Paris
Volume93
Issue number1-2
DOIs
StatePublished - 1999

Keywords

  • Bistability
  • Monoamines
  • Motoneuron
  • Noradrenalin
  • Plateau potential
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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