The role radius of curvature plays in thiolated oligonucleotide loading on gold nanoparticles

Haley D. Hill; Jill E. Millstone; Matthew J. Banholzer; Chad A. Mirkin

doi:10.1021/nn800726e

The role radius of curvature plays in thiolated oligonucleotide loading on gold nanoparticles

Haley D. Hill, Jill E. Millstone, Matthew J. Banholzer, Chad A. Mirkin

Chemistry

Research output: Contribution to journal › Article › peer-review

436 Scopus citations

Abstract

We show that by correlating the radius of curvature of spherical gold nanoparticles of varying sizes with their respective thiol-terminated oligonucleotide loading densities, a mathematical relationship can be derived for predicting the loading of oligonucleotides on anisotropic gold nanomaterials. This mathematical relationship was tested with gold nanorods (radius 17.5 nm, length 475 nm) where the measured number of oligonucleotides per rod (3330 ±110) was within experimental error of the predicted loading of 3244 oligonucleotides from the derivation. Additionally, we show that once gold nanoparticles reach a diameter of approximately 60 nm the local surface experienced by the oligonucleotide is highly similar to that of a planar surface.

Original language	English (US)
Pages (from-to)	418-424
Number of pages	7
Journal	ACS nano
Volume	3
Issue number	2
DOIs	https://doi.org/10.1021/nn800726e
State	Published - Feb 24 2009

Keywords

Curvature
DNA-functionalized
Gold nanoparticle
Gold nanorod
Loading

ASJC Scopus subject areas

General Engineering
General Physics and Astronomy
General Materials Science

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10.1021/nn800726e

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abstract = "We show that by correlating the radius of curvature of spherical gold nanoparticles of varying sizes with their respective thiol-terminated oligonucleotide loading densities, a mathematical relationship can be derived for predicting the loading of oligonucleotides on anisotropic gold nanomaterials. This mathematical relationship was tested with gold nanorods (radius 17.5 nm, length 475 nm) where the measured number of oligonucleotides per rod (3330 ±110) was within experimental error of the predicted loading of 3244 oligonucleotides from the derivation. Additionally, we show that once gold nanoparticles reach a diameter of approximately 60 nm the local surface experienced by the oligonucleotide is highly similar to that of a planar surface.",

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AB - We show that by correlating the radius of curvature of spherical gold nanoparticles of varying sizes with their respective thiol-terminated oligonucleotide loading densities, a mathematical relationship can be derived for predicting the loading of oligonucleotides on anisotropic gold nanomaterials. This mathematical relationship was tested with gold nanorods (radius 17.5 nm, length 475 nm) where the measured number of oligonucleotides per rod (3330 ±110) was within experimental error of the predicted loading of 3244 oligonucleotides from the derivation. Additionally, we show that once gold nanoparticles reach a diameter of approximately 60 nm the local surface experienced by the oligonucleotide is highly similar to that of a planar surface.

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KW - Loading

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The role radius of curvature plays in thiolated oligonucleotide loading on gold nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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