The role radius of curvature plays in thiolated oligonucleotide loading on gold nanoparticles

Haley D. Hill, Jill E. Millstone, Matthew J. Banholzer, Chad A. Mirkin

Research output: Contribution to journalArticlepeer-review

361 Scopus citations

Abstract

We show that by correlating the radius of curvature of spherical gold nanoparticles of varying sizes with their respective thiol-terminated oligonucleotide loading densities, a mathematical relationship can be derived for predicting the loading of oligonucleotides on anisotropic gold nanomaterials. This mathematical relationship was tested with gold nanorods (radius 17.5 nm, length 475 nm) where the measured number of oligonucleotides per rod (3330 ±110) was within experimental error of the predicted loading of 3244 oligonucleotides from the derivation. Additionally, we show that once gold nanoparticles reach a diameter of approximately 60 nm the local surface experienced by the oligonucleotide is highly similar to that of a planar surface.

Original languageEnglish (US)
Pages (from-to)418-424
Number of pages7
JournalACS nano
Volume3
Issue number2
DOIs
StatePublished - Feb 24 2009

Keywords

  • Curvature
  • DNA-functionalized
  • Gold nanoparticle
  • Gold nanorod
  • Loading

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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