The roles of anxiety and depression in connecting tic severity and functional impairment

Adam B. Lewin*, Eric A. Storch, Christine A. Conelea, Douglas W. Woods, Samuel H. Zinner, Cathy L. Budman, Lawrence D. Scahill, Scott N. Compton, John T. Walkup, Tanya K. Murphy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The current study examined relationships between tic severity and both functional impairment and perceived quality of life (QOL) in adults with a chronic tic disorder. The authors explored whether these relationships were moderated by anxiety and depressive symptoms. Five-hundred adults with Tourette's Disorder, Chronic Motor Tic Disorder, or Chronic Vocal Tic Disorder participated in a comprehensive self-report internet-based survey. Anxiety and depressive symptoms moderated the relationship between tic severity and functional impairment such that stronger relationships were documented in participants with elevated depressive or anxious symptoms. Limitations and implications for research and clinical practice are discussed.

Original languageEnglish (US)
Pages (from-to)164-168
Number of pages5
JournalJournal of Anxiety Disorders
Issue number2
StatePublished - Mar 1 2011


  • Anxiety
  • Chronic tic disorder
  • Depression
  • Impairment
  • Severity
  • Tourette's Disorders

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'The roles of anxiety and depression in connecting tic severity and functional impairment'. Together they form a unique fingerprint.

Cite this