The roles of dermal white adipose tissue loss in scleroderma skin fibrosis

Roberta G. Marangoni, Theresa T. Lu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Purpose of review: Dermal white adipose tissue (DWAT) is distinct from subcutaneous white adipose tissue and is lost in scleroderma skin fibrosis. The roles of DWAT loss in scleroderma skin fibrosis have not been well understood, and here we discuss recent findings that begin to provide insight into the multiple mechanisms involved. Recent findings: The DWAT loss in part reflects the direct contribution of DWAT cells to the fibrotic tissue, with the reprogramming of adipocytes to myofibroblasts. The DWAT contains reparative adipose-derived stromal cells and expresses antifibrotic cytokines such as adiponectin, and the loss of these skin-protective mechanisms with DWAT loss further contributes to skin fibrosis and injury. Summary: Potentially, halting or reversing the transdifferentiation of adipocytes to myofibroblasts along with improving survival of reparative adipose-derived stromal cells (ADSCs) and expression of antifibrotic cytokines may be effective therapeutic avenues.

Original languageEnglish (US)
Pages (from-to)585-590
Number of pages6
JournalCurrent opinion in rheumatology
Volume29
Issue number6
DOIs
StatePublished - Nov 1 2017

Keywords

  • dermal white adipose tissue
  • mesenchymal stromal cells
  • myofibroblasts
  • scleroderma
  • skin fibrosis

ASJC Scopus subject areas

  • Rheumatology

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