The Roles of SIRT1 in Cancer

Zhenghong Lin, Deyu Fang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations

Abstract

The sirtuin family has emerged as important regulators of diverse physiological and pathological events, including life-span extension, neurodegeneration, age-related disorders, obesity, heart disease, inflammation, and cancer. In mammals, there are 7 members (SIRT1-SIRT7) in the sirtuin family, with the function of SIRT1 being extensively studied in the past decade. SIRT1 can deacetylate histones and a number of nonhistone substrates, which are involved in multiple signaling pathways. Numerous studies have suggested that SIRT1 could act as either a tumor suppressor or tumor promoter depending on its targets in specific signaling pathways or in specific cancers. This review highlights the major pathways regulated by SIRT1 involved in tumorigenesis.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalGenes and Cancer
Volume4
Issue number3-4
DOIs
StatePublished - Mar 2013

Keywords

  • SIRT1
  • cancer
  • deacetylase

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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