The roles of steroidogenic factor-1 in reproductive function

Keith L. Parker*, Yayoi Ikeda, Xunrong Luo

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The cytochrome P450 steroid hydroxylases are expressed in a tissue- specific and developmentally regulated manner, and the orphan nuclear receptor steroidogenic factor 1 (SF-1) participates in both aspects of regulated expression. SF-1 is expressed in mouse embryos from the inception of adrenal and gonadal development, suggesting that SF-1 plays important roles in their differentiation. SF-1 is also expressed in the embryonic pituitary gland and ventral diencephalon, suggesting additional roles within the hypothalamic-pituitary-steroidogenic organ axis. To examine the roles of SF-1 in vivo, we used targeted gene disruption to 'knock out' the mouse gene encoding SF-1. Analyses of these knockout mice established roles of SF-1 at levels of endocrine development that include adrenal and gonadal differentiation, pituitary gonadotrope function, and formation of the ventromedial hypothalamic nucleus. These results indicate that SF-1 plays multiple roles in endocrine development that are essential for reproduction.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalSteroids
Volume61
Issue number4
DOIs
StatePublished - Apr 1996

Keywords

  • hydroxylase
  • hypothalamic- pituitary-steroidogenic organ axis
  • nuclear receptor
  • sexual differentiation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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