The signal recognition particle

R. J. Keenan*, D. M. Freymann, R. M. Stroud, P. Walter

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

485 Scopus citations


The signal recognition panicle (SRP) and its membrane-associated receptor (SR) catalyze targeting of nascent secretory and membrane proteins to the protein translocation apparatus of the cell. Components of the SRP pathway and salient features of the molecular mechanism of SRP-dependent protein targeting are conserved in all three kingdoms of life, Recent advances in the structure determination of a number of key components in the eukaryotic and prokaryotic SRP pathway provide new insight into the molecular basis of SRP function, and they set the stage for future work toward an integrated picture that takes into account the dynamic and contextual properties of this remarkable cellular machine.

Original languageEnglish (US)
Pages (from-to)755-775
Number of pages21
JournalAnnual review of biochemistry
StatePublished - 2001


  • Alu domain
  • Ffh
  • FtsY
  • GTPase
  • SRP
  • SRP receptor
  • SRP54
  • SRP9/14
  • Signal sequence

ASJC Scopus subject areas

  • Biochemistry


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