Abstract
Voltage-gated sodium channels (Navs) initiate the action potential waveforms in excitable cells. The molecular mechanisms controlling this process have been actively debated. New prokaryotic Nav structures by Wisedchaisri et al. have completed our understanding of the molecular conformations required for cellular electrical signaling, and provide key templates for research to examine eukaryotic Navs.
Original language | English (US) |
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Pages (from-to) | 718-720 |
Number of pages | 3 |
Journal | Trends in Pharmacological Sciences |
Volume | 40 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2019 |
Keywords
- gating charge
- membrane protein
- resting state
- sodium channel
- voltage-dependent channel gating
- voltage-gated ion channel
ASJC Scopus subject areas
- Toxicology
- Pharmacology