The Sodium Channel Voltage Sensor Slides to Rest

Vladimir Yarov-Yarovoy*, Paul DeCaen

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


Voltage-gated sodium channels (Navs) initiate the action potential waveforms in excitable cells. The molecular mechanisms controlling this process have been actively debated. New prokaryotic Nav structures by Wisedchaisri et al. have completed our understanding of the molecular conformations required for cellular electrical signaling, and provide key templates for research to examine eukaryotic Navs.

Original languageEnglish (US)
Pages (from-to)718-720
Number of pages3
JournalTrends in Pharmacological Sciences
Issue number10
StatePublished - Oct 2019


  • gating charge
  • membrane protein
  • resting state
  • sodium channel
  • voltage-dependent channel gating
  • voltage-gated ion channel

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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