The spectra of point mutations in vertebrate genomes

Guenter Albrecht-Buehler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


In spite of the importance of point mutations for evolution and human diseases, their natural spectrum of incidence in different species is not known. Here I propose to determine these spectra by comparing consecutive sequence periods in stretches of repetitive DNA. The article presents the analysis of more than 51,000 such point mutations identified by this approach in the genomes of human, chimpanzee, rat, mouse, pufferfish, zebrafish, and sea squirt. I propose to explain the observed spectra by auto-mutagenic mechanisms of genome variation involving the inter-conversions of nucleotides, single base-pair inversions and their combinations.

Original languageEnglish (US)
Pages (from-to)98-106
Number of pages9
Issue number1
StatePublished - 2009


  • Auto-mutagenesis
  • Evolution
  • Point mutation
  • Repetitive DNA

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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