The spermatid plasma membrane comes of age

James R. Bartles*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Spermiogenesis affords a unique opportunity to examine the formation of plasma membrane domains. Recent attempts to chart the life cycles of well-characterized integral plasma membrane proteins during spermiogenesis have suggested that spermatids are at least as adept as epithelial cells or neurons at establishing their plasma membrane domains. They appear to expand upon the standard recipe involving concurrent domain-specific protein targeting and diffusion barriers by using a combination of intracellular storage within the secretory pathway, developmentally-regulated delivery to provisional plasma membrane domains, large-scale redistributions of diffusion barriers and integral plasma membrane proteins, and the shedding of an entire plasma membrane domain.

Original languageEnglish (US)
Pages (from-to)400-404
Number of pages5
JournalTrends in Cell Biology
Issue number10
StatePublished - Oct 1995

ASJC Scopus subject areas

  • Cell Biology

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