The state of melanoma: challenges and opportunities

Glenn Merlino; Meenhard Herlyn; David E. Fisher; Boris C. Bastian; Keith T. Flaherty; Michael A. Davies; Jennifer A. Wargo; Clara Curiel-Lewandrowski; Michael J. Weber; Sancy A. Leachman; Maria S. Soengas; Martin McMahon; J. William Harbour; Susan M. Swetter; Andrew E. Aplin; Michael B. Atkins; Marcus W. Bosenberg; Reinhard Dummer; Jeffrey E. Gershenwald; Allan C. Halpern; Dorothee Herlyn; Giorgos C. Karakousis; John M. Kirkwood; Michael Krauthammer; Roger S. Lo; Georgina V. Long; Grant McArthur; Antoni Ribas; Lynn Schuchter; Jeffrey A. Sosman; Keiran S. Smalley; Patricia Steeg; Nancy E. Thomas; Hensin Tsao; Thomas Tueting; Ashani Weeraratna; George Xu; Randy Lomax; Alison Martin; Steve Silverstein; Tim Turnham; Ze'ev A. Ronai

doi:10.1111/pcmr.12475

The state of melanoma: challenges and opportunities

Glenn Merlino, Meenhard Herlyn, David E. Fisher, Boris C. Bastian, Keith T. Flaherty, Michael A. Davies, Jennifer A. Wargo, Clara Curiel-Lewandrowski, Michael J. Weber, Sancy A. Leachman, Maria S. Soengas, Martin McMahon, J. William Harbour, Susan M. Swetter, Andrew E. Aplin, Michael B. Atkins, Marcus W. Bosenberg, Reinhard Dummer, Jeffrey E. Gershenwald, Allan C. HalpernDorothee Herlyn, Giorgos C. Karakousis, John M. Kirkwood, Michael Krauthammer, Roger S. Lo, Georgina V. Long, Grant McArthur, Antoni Ribas, Lynn Schuchter, Jeffrey A. Sosman, Keiran S. Smalley, Patricia Steeg, Nancy E. Thomas, Hensin Tsao, Thomas Tueting, Ashani Weeraratna, George Xu, Randy Lomax, Alison Martin, Steve Silverstein, Tim Turnham, Ze'ev A. Ronai^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long-term needs of the melanoma field, from basic research to clinical management, are presented in the following report.

Original language	English (US)
Pages (from-to)	404-416
Number of pages	13
Journal	Pigment Cell and Melanoma Research
Volume	29
Issue number	4
DOIs	https://doi.org/10.1111/pcmr.12475
State	Published - Jul 1 2016

Funding

Keywords

dormancy
early diagnosis
melanoma
metastasis
prevention
therapy

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Dermatology
Oncology

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10.1111/pcmr.12475

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Merlino, G., Herlyn, M., Fisher, D. E., Bastian, B. C., Flaherty, K. T., Davies, M. A., Wargo, J. A., Curiel-Lewandrowski, C., Weber, M. J., Leachman, S. A., Soengas, M. S., McMahon, M., Harbour, J. W., Swetter, S. M., Aplin, A. E., Atkins, M. B., Bosenberg, M. W., Dummer, R., Gershenwald, J. E., ... Ronai, Z. A. (2016). The state of melanoma: challenges and opportunities. Pigment Cell and Melanoma Research, 29(4), 404-416. https://doi.org/10.1111/pcmr.12475

@article{d12c1aef57cc435ab071e051af3ec4be,

title = "The state of melanoma: challenges and opportunities",

abstract = "The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long-term needs of the melanoma field, from basic research to clinical management, are presented in the following report.",

keywords = "dormancy, early diagnosis, melanoma, metastasis, prevention, therapy",

author = "Glenn Merlino and Meenhard Herlyn and Fisher, {David E.} and Bastian, {Boris C.} and Flaherty, {Keith T.} and Davies, {Michael A.} and Wargo, {Jennifer A.} and Clara Curiel-Lewandrowski and Weber, {Michael J.} and Leachman, {Sancy A.} and Soengas, {Maria S.} and Martin McMahon and Harbour, {J. William} and Swetter, {Susan M.} and Aplin, {Andrew E.} and Atkins, {Michael B.} and Bosenberg, {Marcus W.} and Reinhard Dummer and Gershenwald, {Jeffrey E.} and Halpern, {Allan C.} and Dorothee Herlyn and Karakousis, {Giorgos C.} and Kirkwood, {John M.} and Michael Krauthammer and Lo, {Roger S.} and Long, {Georgina V.} and Grant McArthur and Antoni Ribas and Lynn Schuchter and Sosman, {Jeffrey A.} and Smalley, {Keiran S.} and Patricia Steeg and Thomas, {Nancy E.} and Hensin Tsao and Thomas Tueting and Ashani Weeraratna and George Xu and Randy Lomax and Alison Martin and Steve Silverstein and Tim Turnham and Ronai, {Ze'ev A.}",

note = "Publisher Copyright: {\textcopyright} 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2016",

month = jul,

day = "1",

doi = "10.1111/pcmr.12475",

language = "English (US)",

volume = "29",

pages = "404--416",

journal = "Pigment Cell and Melanoma Research",

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Merlino, G, Herlyn, M, Fisher, DE, Bastian, BC, Flaherty, KT, Davies, MA, Wargo, JA, Curiel-Lewandrowski, C, Weber, MJ, Leachman, SA, Soengas, MS, McMahon, M, Harbour, JW, Swetter, SM, Aplin, AE, Atkins, MB, Bosenberg, MW, Dummer, R, Gershenwald, JE, Halpern, AC, Herlyn, D, Karakousis, GC, Kirkwood, JM, Krauthammer, M, Lo, RS, Long, GV, McArthur, G, Ribas, A, Schuchter, L, Sosman, JA, Smalley, KS, Steeg, P, Thomas, NE, Tsao, H, Tueting, T, Weeraratna, A, Xu, G, Lomax, R, Martin, A, Silverstein, S, Turnham, T & Ronai, ZA 2016, 'The state of melanoma: challenges and opportunities', Pigment Cell and Melanoma Research, vol. 29, no. 4, pp. 404-416. https://doi.org/10.1111/pcmr.12475

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T1 - The state of melanoma

T2 - challenges and opportunities

AU - Merlino, Glenn

AU - Herlyn, Meenhard

AU - Fisher, David E.

AU - Bastian, Boris C.

AU - Flaherty, Keith T.

AU - Davies, Michael A.

AU - Wargo, Jennifer A.

AU - Curiel-Lewandrowski, Clara

AU - Weber, Michael J.

AU - Leachman, Sancy A.

AU - Soengas, Maria S.

AU - McMahon, Martin

AU - Harbour, J. William

AU - Swetter, Susan M.

AU - Aplin, Andrew E.

AU - Atkins, Michael B.

AU - Bosenberg, Marcus W.

AU - Dummer, Reinhard

AU - Gershenwald, Jeffrey E.

AU - Halpern, Allan C.

AU - Herlyn, Dorothee

AU - Karakousis, Giorgos C.

AU - Kirkwood, John M.

AU - Krauthammer, Michael

AU - Lo, Roger S.

AU - Long, Georgina V.

AU - McArthur, Grant

AU - Ribas, Antoni

AU - Schuchter, Lynn

AU - Sosman, Jeffrey A.

AU - Smalley, Keiran S.

AU - Steeg, Patricia

AU - Thomas, Nancy E.

AU - Tsao, Hensin

AU - Tueting, Thomas

AU - Weeraratna, Ashani

AU - Xu, George

AU - Lomax, Randy

AU - Martin, Alison

AU - Silverstein, Steve

AU - Turnham, Tim

AU - Ronai, Ze'ev A.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long-term needs of the melanoma field, from basic research to clinical management, are presented in the following report.

AB - The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long-term needs of the melanoma field, from basic research to clinical management, are presented in the following report.

KW - dormancy

KW - early diagnosis

KW - melanoma

KW - metastasis

KW - prevention

KW - therapy

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U2 - 10.1111/pcmr.12475

DO - 10.1111/pcmr.12475

M3 - Article

C2 - 27087480

AN - SCOPUS:84975700666

SN - 1755-1471

VL - 29

SP - 404

EP - 416

JO - Pigment Cell and Melanoma Research

JF - Pigment Cell and Melanoma Research

IS - 4

ER -

The state of melanoma: challenges and opportunities

Abstract

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Keywords

ASJC Scopus subject areas

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