The state of the STATs: Recent developments in the study of signal transduction to the nucleus

Curt M. Horvath*, James E. Darnell

*Corresponding author for this work

Research output: Contribution to journalArticle

162 Scopus citations

Abstract

The STATs (signal transducers and activators of transcription) are latent cytoplasmic proteins that, upon activation by cell surface bound polypeptide ligands, move to the nucleus to direct transcription. A variety of protein-protein interactions that affect the function of STATs has been recently recognized. It has become clear that the STATs are functional mosaics, or mixtures of signal transduction and transcription modules.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume9
Issue number2
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Cell Biology

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