The stimulation of thrombosis by hypoxia

Neha Gupta, You Yang Zhao, Colin E. Evans*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations

Abstract

Thrombus formation is increased under conditions of hypoxia in animal models of thrombosis and in human populations, but current therapies for thrombosis do not directly target hypoxia-responsive signaling pathways. The vascular response to hypoxia is controlled primarily by the hypoxia-inducible transcription factors (HIFs), whose target genes include several factors that regulate thrombus formation. In this article, we review the HIF-dependent and HIF-independent signaling pathways that regulate thrombus formation under hypoxic conditions. A better understanding of hypoxia-induced thrombus formation could lead to the development of novel prophylactic therapies for thrombosis.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalThrombosis research
Volume181
DOIs
StatePublished - Sep 2019

Keywords

  • Hypoxia
  • Hypoxia-inducible factor
  • Thrombosis
  • Thrombus formation

ASJC Scopus subject areas

  • Hematology

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